SORT1 and ADGRG7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SORT1	ADGRG7
Description		sortilin 1	adhesion G protein-coupled receptor G7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Lysosome Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Endosome Membrane Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm Cerebellar Climbing Fiber To Purkinje Cell Synapse	Plasma Membrane Membrane
	Molecular Function	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G Protein-coupled Nerve Growth Factor Binding Retromer Complex Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Ossification Protein Targeting To Lysosome Golgi To Endosome Transport Endocytosis G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Cell Differentiation Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Negative Regulation Of Fat Cell Differentiation D-glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Golgi To Lysosome Transport Maintenance Of Synapse Structure	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Appendicular lean mass ( 33097823) Cholesterol, total ( 24097068 25961943 20686565) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Coronary artery disease ( 21239051 24262325 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378988 21378990) Coronary heart disease x type 2 diabetes interaction ( 32541925) HDL cholesterol ( 25961943) LDL cholesterol ( 18193044 25961943 18193043 19060906 19060910 24097068 20686565 21347282) LDL cholesterol levels ( 26690388 28334899) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 30718733) Metabolite levels ( 21909109) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Ratio of apolipoprotein A1 to apolipoprotein B ( 29084231) Response to statin therapy ( 20339536) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Total cholesterol levels ( 28334899)
Interacting Genes		17 interacting genes: ADGRG7 BDNF BRICD5 CNIH3 GGA1 GGA2 LRPAP1 NGF NGFR NTF3 NTRK1 NTRK2 NTRK3 NTS SORCS1 SORL1 TF	4 interacting genes: LDLRAD1 LMNA SORT1 VAPA
Entrez ID		6272	84873
HPRD ID		03910	17060
Ensembl ID		ENSG00000134243	ENSG00000144820
Uniprot IDs		Q99523	B7Z303 E9PHI0 Q6ZMH4 Q96K78
PDB IDs		3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO 6X3L 6X48 6X4H 8T8R 8T8S
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin Binding Nerve Development Nerve Growth Factor Signaling Pathway Neurotrophin Receptor Activity Nerve Growth Factor Receptor Binding Endosome Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Endosome Membrane Positive Regulation Of Neuron Projection Development Positive Regulation Of Synapse Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Axonogenesis Early Endosome Membrane Enzyme-linked Receptor Protein Signaling Pathway Axon Mechanoreceptor Differentiation Regulation Of Nervous System Development Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cell Junction Assembly Dendrite Regulation Of Neuron Apoptotic Process Rhythmic Process Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Nervous System Development Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Nerve Growth Factor Binding Cellular Response To Nerve Growth Factor Stimulus Regulation Of Axonogenesis Signal Transduction Nervous System Development Early Endosome Response To Nerve Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synapse Assembly Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Regulation Of Signal Transduction Establishment Of Protein Localization To Plasma Membrane System Development Signaling Receptor Binding Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development	Nuclear Membrane Protein Localization To Organelle Perinuclear Region Of Cytoplasm Neurotensin Receptor Activity, Non-G Protein-coupled DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Nerve Growth Factor Receptor Activity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Cellular Localization Ventricular Cardiac Muscle Cell Development Nuclear Pore Localization Establishment Of Protein Localization To Organelle Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Mesenchymal Cell Proliferation Intracellular Transport Vesicle Organization Golgi To Lysosome Transport Plasma Membrane To Endosome Transport Vesicle-mediated Transport Retromer Complex Binding Golgi Vesicle Transport Nerve Growth Factor Binding Cerebellar Climbing Fiber To Purkinje Cell Synapse Endoplasmic Reticulum Localization FFAT Motif Binding Host-mediated Activation Of Viral Genome Replication COPII-coated Vesicle Budding Sphingomyelin Biosynthetic Process Endoplasmic Reticulum-plasma Membrane Tethering Host-mediated Perturbation Of Viral Genome Replication Establishment Of Localization In Cell Protein Folding In Endoplasmic Reticulum Nuclear Lamina Host-mediated Suppression Of Viral Genome Replication Protein Localization To Nuclear Envelope Golgi To Endosome Transport Nerve Growth Factor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Organelle Localization Negative Regulation Of Release Of Cytochrome C From Mitochondria Intracellular Protein Localization Golgi To Vacuole Transport Trans-Golgi Network Transport Vesicle D-glucose Import Protein Localization To Endoplasmic Reticulum Ceramide Transport Sphingomyelin Metabolic Process Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nuclear Envelope Organization
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