NGF and NGFR

Number of citations of the paper that reports this interaction (PMID 11729324)
261

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		NGF	NGFR
Gene Name		nerve growth factor (beta polypeptide)	nerve growth factor receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Golgi Lumen Cytoplasmic Membrane-bounded Vesicle	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Neuronal Postsynaptic Density
	Molecular Function	Receptor Signaling Protein Activity Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Rab GTPase Binding Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding
	Biological Process	Activation Of MAPKK Activity Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Peripheral Nervous System Development Memory Circadian Rhythm Adult Locomotory Behavior Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Radiation Response To Mechanical Stimulus Response To Ozone Positive Regulation Of Gene Expression Positive Regulation Of Neuron Maturation Sensory Perception Of Pain Positive Regulation Of Protein Autophosphorylation Nerve Growth Factor Processing Response To Lipopolysaccharide Response To Nicotine Nerve Growth Factor Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Cell Cycle Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Glucocorticoid Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Response To Electrical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Intracellular Protein Transport Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Regulation Of Hair Follicle Development Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways		Retrograde neurotrophin signalling Signalling to ERKs Prolonged ERK activation events NF-kB is activated and signals survival p75NTR recruits signalling complexes Axonal growth stimulation Ceramide signalling PI3K/AKT activation p75NTR signals via NF-kB NGF processing NFG and proNGF binds to p75NTR Signalling to p38 via RIT and RIN Signalling by NGF p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Activation of TRKA receptors p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF NRIF signals cell death from the nucleus Signalling to RAS NRAGE signals death through JNK Signalling to STAT3 PLC-gamma1 signalling NADE modulates death signalling Frs2-mediated activation	Regulated proteolysis of p75NTR Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Axonal growth stimulation Ceramide signalling p75 NTR receptor-mediated signalling Axonal growth inhibition (RHOA activation) NRIF signals cell death from the nucleus NRAGE signals death through JNK p75NTR signals via NF-kB NFG and proNGF binds to p75NTR NADE modulates death signalling
Drugs		Clenbuterol
Diseases
GWAS		Non-alcoholic fatty liver disease ( 23535911)	Immune reponse to smallpox (secreted IL-2) ( 22610502) Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: A2M CRYAB MMP7 NGFR NTRK1 PLG SORCS3 SORT1	45 interactors: ANXA7 BEX1 CAV1 CD80 CDKN1A FSCN1 GRB2 H2AFX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 NDN NDNL2 NFKBIB NGF NGFRAP1 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1L ZNF274
Entrez ID		4803	4804
HPRD ID		08874	01197
Ensembl ID		ENSG00000134259	ENSG00000064300
Uniprot IDs		P01138	P08138
PDB IDs		1SG1 1WWW 2IFG	3EWV
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Nerve Growth Factor Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Detection Of Temperature Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Developmental Programmed Cell Death Cell Differentiation Extracellular Matrix Organization Programmed Cell Death Extracellular Structure Organization Response To Stimulus Regulation Of Endopeptidase Activity Cell Death Death Negative Regulation Of Hydrolase Activity Platelet Degranulation Regulation Of Peptidase Activity Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Neuropeptide Signaling Pathway Regulation Of Catalytic Activity Nerve Development Muscle Structure Development Negative Regulation Of Complement Activation, Lectin Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Proliferation Secretion Regulation Of Long Term Synaptic Depression Mononuclear Cell Migration Negative Regulation Of Hair Follicle Development Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Fibrinolysis Circadian Rhythm Detection Of Abiotic Stimulus Negative Regulation Of Catalytic Activity Response To Temperature Stimulus Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Cysteine-type Endopeptidase Activity Signal Transduction Axonogenesis Involved In Innervation	Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development TRIF-dependent Toll-like Receptor Signaling Pathway Response To Stimulus Developmental Process Regulation Of MAP Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Tagcloud ?		afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small	acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Difference) ?		afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small	acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Intersection) ?