NGF and NTRK1

Number of citations of the paper that reports this interaction (PMID 14985763)
143

Data Source:
BioGRID (x-ray crystallography, x-ray crystallography)
HPRD (in vitro, in vivo)

		NGF	NTRK1
Gene Name		nerve growth factor (beta polypeptide)	neurotrophic tyrosine kinase, receptor, type 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Golgi Lumen Cytoplasmic Membrane-bounded Vesicle	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Neuronal Cell Body Protein Complex Receptor Complex
	Molecular Function	Receptor Signaling Protein Activity Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Nerve Growth Factor Binding
	Biological Process	Activation Of MAPKK Activity Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Peripheral Nervous System Development Memory Circadian Rhythm Adult Locomotory Behavior Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Radiation Response To Mechanical Stimulus Response To Ozone Positive Regulation Of Gene Expression Positive Regulation Of Neuron Maturation Sensory Perception Of Pain Positive Regulation Of Protein Autophosphorylation Nerve Growth Factor Processing Response To Lipopolysaccharide Response To Nicotine Nerve Growth Factor Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Cell Cycle Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Glucocorticoid Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Response To Electrical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Activation Of MAPKK Activity Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Aging Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Developmental Programmed Cell Death Positive Regulation Of Neuron Projection Development Response To Activity Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development B Cell Differentiation Response To Nutrient Levels Positive Regulation Of Ras GTPase Activity Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Sympathetic Nervous System Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Axonogenesis Involved In Innervation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Nerve Growth Factor Stimulus
Pathways		Retrograde neurotrophin signalling Signalling to ERKs Prolonged ERK activation events NF-kB is activated and signals survival p75NTR recruits signalling complexes Axonal growth stimulation Ceramide signalling PI3K/AKT activation p75NTR signals via NF-kB NGF processing NFG and proNGF binds to p75NTR Signalling to p38 via RIT and RIN Signalling by NGF p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Activation of TRKA receptors p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF NRIF signals cell death from the nucleus Signalling to RAS NRAGE signals death through JNK Signalling to STAT3 PLC-gamma1 signalling NADE modulates death signalling Frs2-mediated activation	Retrograde neurotrophin signalling Signalling to ERKs Signalling by NGF Prolonged ERK activation events Activation of TRKA receptors NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF PI3K/AKT activation Signalling to RAS Signalling to STAT3 NGF-independant TRKA activation PLC-gamma1 signalling Signalling to p38 via RIT and RIN Frs2-mediated activation
Drugs		Clenbuterol	Amitriptyline Imatinib Regorafenib
Diseases
GWAS		Non-alcoholic fatty liver disease ( 23535911)
Protein-Protein Interactions		8 interactors: A2M CRYAB MMP7 NGFR NTRK1 PLG SORCS3 SORT1	36 interactors: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 FRS2 FRS3 GIPC1 GRB2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4 NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		4803	4914
HPRD ID		08874	01869
Ensembl ID		ENSG00000134259	ENSG00000198400
Uniprot IDs		P01138	P04629
PDB IDs		1SG1 1WWW 2IFG	1HE7 1SHC 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Nerve Growth Factor Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Detection Of Temperature Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Developmental Programmed Cell Death Cell Differentiation Extracellular Matrix Organization Programmed Cell Death Extracellular Structure Organization Response To Stimulus Regulation Of Endopeptidase Activity Cell Death Death Negative Regulation Of Hydrolase Activity Platelet Degranulation Regulation Of Peptidase Activity Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Neuropeptide Signaling Pathway Regulation Of Catalytic Activity Nerve Development Muscle Structure Development Negative Regulation Of Complement Activation, Lectin Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Proliferation Secretion Regulation Of Long Term Synaptic Depression Mononuclear Cell Migration Negative Regulation Of Hair Follicle Development Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Fibrinolysis Circadian Rhythm Detection Of Abiotic Stimulus Negative Regulation Of Catalytic Activity Response To Temperature Stimulus Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Cysteine-type Endopeptidase Activity Signal Transduction Axonogenesis Involved In Innervation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Kinase Activity Cell Communication Regulation Of Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Cellular Response To Insulin Stimulus Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Catalytic Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Positive Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Peptide Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Response To Stimulus Response To Peptide Hormone Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Response To Fibroblast Growth Factor Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity
Tagcloud ?		afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Difference) ?		afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Intersection) ?