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NGF
Gene Name
nerve growth factor (beta polypeptide)
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endosome
Golgi Lumen
Cytoplasmic Membrane-bounded Vesicle
Molecular Function
Receptor Signaling Protein Activity
Nerve Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Biological Process
Activation Of MAPKK Activity
Inflammatory Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Activation Of Phospholipase C Activity
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Cell-cell Signaling
Peripheral Nervous System Development
Memory
Circadian Rhythm
Adult Locomotory Behavior
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Response To Radiation
Response To Mechanical Stimulus
Response To Ozone
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Maturation
Sensory Perception Of Pain
Positive Regulation Of Protein Autophosphorylation
Nerve Growth Factor Processing
Response To Lipopolysaccharide
Response To Nicotine
Nerve Growth Factor Signaling Pathway
Response To Drug
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Peptide Hormone
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Differentiation
Positive Regulation Of Axon Extension
Negative Regulation Of Cell Cycle
Regulation Of Neurotransmitter Secretion
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Neuron Projection Morphogenesis
Regulation Of Axonogenesis
Positive Regulation Of Axonogenesis
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Response To Glucocorticoid
Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Neuron Apoptotic Process
Response To Electrical Stimulus
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Stem Cell Proliferation
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways
Retrograde neurotrophin signalling
Signalling to ERKs
Prolonged ERK activation events
NF-kB is activated and signals survival
p75NTR recruits signalling complexes
Axonal growth stimulation
Ceramide signalling
PI3K/AKT activation
p75NTR signals via NF-kB
NGF processing
NFG and proNGF binds to p75NTR
Signalling to p38 via RIT and RIN
Signalling by NGF
p75NTR regulates axonogenesis
p75NTR negatively regulates cell cycle via SC1
Cell death signalling via NRAGE, NRIF and NADE
Activation of TRKA receptors
p75 NTR receptor-mediated signalling
NGF signalling via TRKA from the plasma membrane
ARMS-mediated activation
TRKA activation by NGF
NRIF signals cell death from the nucleus
Signalling to RAS
NRAGE signals death through JNK
Signalling to STAT3
PLC-gamma1 signalling
NADE modulates death signalling
Frs2-mediated activation
Drugs
Clenbuterol
Diseases
GWAS
Non-alcoholic fatty liver disease (
23535911
)
Protein-protein Interactions
8 interactors:
A2M
CRYAB
MMP7
NGFR
NTRK1
PLG
SORCS3
SORT1
Entrez ID
4803
HPRD ID
08874
Ensembl ID
ENSG00000134259
Uniprot IDs
P01138
PDB IDs
1SG1
1WWW
2IFG
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix Disassembly
Nerve Growth Factor Signaling Pathway
Cellular Response To Nerve Growth Factor Stimulus
Detection Of Temperature Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Developmental Programmed Cell Death
Cell Differentiation
Extracellular Matrix Organization
Programmed Cell Death
Extracellular Structure Organization
Response To Stimulus
Regulation Of Endopeptidase Activity
Cell Death
Death
Negative Regulation Of Hydrolase Activity
Platelet Degranulation
Regulation Of Peptidase Activity
Antibacterial Peptide Secretion
Antibacterial Peptide Biosynthetic Process
Neuropeptide Signaling Pathway
Regulation Of Catalytic Activity
Nerve Development
Muscle Structure Development
Negative Regulation Of Complement Activation, Lectin Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Cell Proliferation
Secretion
Regulation Of Long Term Synaptic Depression
Mononuclear Cell Migration
Negative Regulation Of Hair Follicle Development
Regulation Of Proteolysis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Activation
Response To Wounding
Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Negative Regulation Of Hair Cycle
Positive Regulation Of Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of Fibrinolysis
Circadian Rhythm
Detection Of Abiotic Stimulus
Negative Regulation Of Catalytic Activity
Response To Temperature Stimulus
Platelet Activation
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Endosome Transport Via Multivesicular Body Sorting Pathway
Regulation Of Cysteine-type Endopeptidase Activity
Signal Transduction
Axonogenesis Involved In Innervation
Tagcloud
?
afferent
antagonist
b1
b2
bk
blocked
cap
capsaicin
completely
cultivation
cultured
depolarization
depolarized
dissociated
dorsal
drg
drgs
freshly
ganglia
insensitive
microm
nerve
neurons
percentage
rat
recordings
root
sensitive
small