NGF and MMP7

Number of citations of the paper that reports this interaction (PMID 11729324)
261

Data Source:
HPRD (in vivo, in vitro)

		NGF	MMP7
Gene Name		nerve growth factor (beta polypeptide)	matrix metallopeptidase 7 (matrilysin, uterine)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Golgi Lumen Cytoplasmic Membrane-bounded Vesicle	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Receptor Signaling Protein Activity Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Activation Of MAPKK Activity Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Peripheral Nervous System Development Memory Circadian Rhythm Adult Locomotory Behavior Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Radiation Response To Mechanical Stimulus Response To Ozone Positive Regulation Of Gene Expression Positive Regulation Of Neuron Maturation Sensory Perception Of Pain Positive Regulation Of Protein Autophosphorylation Nerve Growth Factor Processing Response To Lipopolysaccharide Response To Nicotine Nerve Growth Factor Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Cell Cycle Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Glucocorticoid Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Response To Electrical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Regulation Of Cell Proliferation Response To Drug Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		Retrograde neurotrophin signalling Signalling to ERKs Prolonged ERK activation events NF-kB is activated and signals survival p75NTR recruits signalling complexes Axonal growth stimulation Ceramide signalling PI3K/AKT activation p75NTR signals via NF-kB NGF processing NFG and proNGF binds to p75NTR Signalling to p38 via RIT and RIN Signalling by NGF p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Activation of TRKA receptors p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF NRIF signals cell death from the nucleus Signalling to RAS NRAGE signals death through JNK Signalling to STAT3 PLC-gamma1 signalling NADE modulates death signalling Frs2-mediated activation	Collagen formation Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs		Clenbuterol
Diseases
GWAS		Non-alcoholic fatty liver disease ( 23535911)	Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: A2M CRYAB MMP7 NGFR NTRK1 PLG SORCS3 SORT1	16 interactors: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11
Entrez ID		4803	4316
HPRD ID		08874	01525
Ensembl ID		ENSG00000134259	ENSG00000137673
Uniprot IDs		P01138	P09237
PDB IDs		1SG1 1WWW 2IFG	1MMP 1MMQ 1MMR 2DDY 2Y6C 2Y6D
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Nerve Growth Factor Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Detection Of Temperature Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Developmental Programmed Cell Death Cell Differentiation Extracellular Matrix Organization Programmed Cell Death Extracellular Structure Organization Response To Stimulus Regulation Of Endopeptidase Activity Cell Death Death Negative Regulation Of Hydrolase Activity Platelet Degranulation Regulation Of Peptidase Activity Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Neuropeptide Signaling Pathway Regulation Of Catalytic Activity Nerve Development Muscle Structure Development Negative Regulation Of Complement Activation, Lectin Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Proliferation Secretion Regulation Of Long Term Synaptic Depression Mononuclear Cell Migration Negative Regulation Of Hair Follicle Development Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Fibrinolysis Circadian Rhythm Detection Of Abiotic Stimulus Negative Regulation Of Catalytic Activity Response To Temperature Stimulus Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Cysteine-type Endopeptidase Activity Signal Transduction Axonogenesis Involved In Innervation	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Cell Motility Wound Healing Response To Wounding Immune System Process Locomotion System Development Response To Stress Movement Of Cell Or Subcellular Component Multicellular Organismal Development Organ Development Regulation Of Endopeptidase Activity Positive Regulation Of Keratinocyte Migration Anatomical Structure Development Regulation Of Peptidase Activity Blood Coagulation Hemostasis Glycosaminoglycan Catabolic Process Response To External Stimulus Response To Organic Substance Pathogenesis Response To Lipid Response To Bacterium Developmental Process Dermatan Sulfate Biosynthetic Process Regulation Of Body Fluid Levels Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Bone Resorption Regulation Of Proteolysis Response To Molecule Of Bacterial Origin Tissue Development Response To Other Organism Response To Biotic Stimulus Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Axonogenesis Defense Response Inflammatory Response Response To Stimulus Positive Regulation Of Tissue Remodeling Glycosaminoglycan Metabolic Process Response To Steroid Hormone
Tagcloud ?		afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small	a549 a549cis a549cisdkk3 adenocarcinoma betacatenin calu1 calu1cis chemosensitivity cisplatin cisplatinresistant cisplatintreated cmyc dickkopf3 dkk3 ecadherin enhances h460 h460cis h460cisdkk3 inactivated parp proportions reactivation realize rendered retarded sb216763 seeded subline
Tagcloud (Difference) ?		afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small	a549 a549cis a549cisdkk3 adenocarcinoma betacatenin calu1 calu1cis chemosensitivity cisplatin cisplatinresistant cisplatintreated cmyc dickkopf3 dkk3 ecadherin enhances h460 h460cis h460cisdkk3 inactivated parp proportions reactivation realize rendered retarded sb216763 seeded subline
Tagcloud (Intersection) ?