NFYA and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 19060904)
32

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		NFYA	APPBP2
Description		nuclear transcription factor Y subunit alpha	amyloid beta precursor protein binding protein 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)	Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		50 interacting genes: APP APPBP2 ATF6 ATF6B ATXN1 BANP BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 DVL3 E2F6 ELF1 EP300 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 POU3F2 PWP1 QRICH1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TOPBP1 TP53 UBL5 USF1 USF2 VEZF1 ZC3H10 ZHX1 ZHX2 ZHX3	122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		4800	10513
HPRD ID		01793	05616
Ensembl ID		ENSG00000001167	ENSG00000062725
Uniprot IDs		P23511	Q92624
PDB IDs		4AWL 6QMP 6QMQ 6QMS 8QU2 8QU3 8QU4	8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Transcription Cis-regulatory Region Binding DNA-templated Transcription Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Cellular Senescence Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Metabolic Process ER-nucleus Signaling Pathway	Protein Binding
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