NFYA and ATF6

Number of citations of the paper that reports this interaction (PMID 11158310)
58

Data Source:
BioGRID (two hybrid)

		NFYA	ATF6
Gene Name		nuclear transcription factor Y, alpha	activating transcription factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Core Promoter Sequence-specific DNA Binding Transcription Cofactor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding CAMP Response Element Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Stem Cell Maintenance Positive Regulation Of Stem Cell Proliferation	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Folding Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins ATF4 activates genes ATF6-alpha activates chaperone genes Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) PERK regulates gene expression ATF6-alpha activates chaperones Unfolded Protein Response (UPR)	ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperone genes ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS			Parkinson's disease (age of onset) ( 19772629)
Protein-Protein Interactions		37 interactors: APP APPBP2 ATF6 ATF6B BRCA1 CCNA2 CDC25A CDK2 CEBPA CSNK2A1 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 PWP1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TP53 USF1 USF2 ZHX1 ZHX2 ZHX3	14 interactors: APP ATF6B BPGM CREB1 CREB3L3 DDC GTF2I NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1
Entrez ID		4800	22926
HPRD ID		01793	16118
Ensembl ID			ENSG00000118217
Uniprot IDs		P23511	A8K383 P18850
PDB IDs		4AWL
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Viral Process Cellular Metabolic Process Positive Regulation Of Transcription By Glucose Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation By Host Of Viral Transcription Negative Regulation Of Nucleic Acid-templated Transcription Metabolic Process Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Late Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cellular Response To Nutrient Levels Regulation Of Cell Cycle	Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Cellular Response To Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Topologically Incorrect Protein Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To Unfolded Protein Response To Organonitrogen Compound Response To Endoplasmic Reticulum Stress Cellular Response To Stimulus Response To Toxic Substance Response To Hormone Small Molecule Metabolic Process Response To Drug Cellular Chemical Homeostasis Response To Stress Response To Abiotic Stimulus Erythrocyte Development Cellular Response To Nutrient Regulation Of Metabolic Process Positive Regulation Of Fat Cell Differentiation
Tagcloud ?		anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nutshell oprk1 pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp usf usf2 vdr vulnerability	ca1 ca3 cerebellar cerebellum colliculus dentate developmentally germinal grp78 grp94 gyrus immature inducer insults manf matured misfolded neurodevelopmental parietal pd12 pd25 pd4 pons subcutaneously subiculum tunicamycin unfolded upr xbp1s
Tagcloud (Difference) ?		anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nutshell oprk1 pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp usf usf2 vdr vulnerability	ca1 ca3 cerebellar cerebellum colliculus dentate developmentally germinal grp78 grp94 gyrus immature inducer insults manf matured misfolded neurodevelopmental parietal pd12 pd25 pd4 pons subcutaneously subiculum tunicamycin unfolded upr xbp1s
Tagcloud (Intersection) ?