NFRKB and UCHL5

Number of citations of the paper that reports this interaction (PMID 18922472)
30

Data Source:
BioGRID (two hybrid, pull down)

		NFRKB	UCHL5
Gene Name		nuclear factor related to kappaB binding protein	ubiquitin carboxyl-terminal hydrolase L5
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Ino80 Complex	Proteasome Complex Nucleus Cytosol Ino80 Complex
	Molecular Function	Protease Binding DNA Binding Protein Binding	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding
	Biological Process	DNA Repair DNA Recombination Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Inflammatory Response	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Cannabis dependence ( 21668797)
Protein-Protein Interactions		4 interactors: EPHB3 NFKB1 TRDMT1 UCHL5	96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1
Entrez ID		4798	51377
HPRD ID		01240	10293
Ensembl ID		ENSG00000170322	ENSG00000116750
Uniprot IDs		Q6P4R8	Q9Y5K5
PDB IDs		3U21	3A7S 3IHR 3RII 3RIS 3TB3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Interleukin-12 Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Vitamin D Biosynthetic Process Telencephalon Development C-5 Methylation Of Cytosine Positive Regulation Of MiRNA Metabolic Process Cellular Response To Nicotine Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Cholesterol Transport Regulation Of MiRNA Metabolic Process Forebrain Development DNA Methylation On Cytosine Negative Regulation Of Monooxygenase Activity Dendritic Spine Morphogenesis Regulation Of Vitamin Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Corpus Callosum Development Dendritic Spine Development Negative Regulation Of Interleukin-12 Production Cellular Response To Growth Factor Stimulus Response To Copper Ion Retinal Ganglion Cell Axon Guidance Dendritic Spine Organization Response To Growth Factor Forebrain Morphogenesis Regulation Of Catalytic Activity Negative Regulation Of Steroid Biosynthetic Process Regulation Of Rac GTPase Activity Negative Regulation Of Lipid Transport TRNA Methylation Lateral Ventricle Development Axonal Fasciculation Negative Regulation Of Steroid Metabolic Process Negative Regulation Of Oxidoreductase Activity Cellular Response To Interleukin-6 Response To Organic Substance Regulation Of Cdc42 GTPase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Response To Interleukin-6 Positive Regulation Of Synapse Assembly Positive Regulation Of Lipid Storage Membrane Protein Proteolysis Response To Amphetamine Regulation Of Signal Transduction Brain Development	Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process
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