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NFRKB and NFKB1
Number of citations of the paper that reports this interaction (PMID
2050119
)
87
Data Source:
HPRD
(in vitro)
NFRKB
NFKB1
Gene Name
nuclear factor related to kappaB binding protein
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Ino80 Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
I-kappaB/NF-kappaB Complex
Molecular Function
Protease Binding
DNA Binding
Protein Binding
Regulatory Region DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
Chromatin Binding
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Heat Shock Protein Binding
Protein Homodimerization Activity
Transcription Regulatory Region DNA Binding
Biological Process
DNA Repair
DNA Recombination
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Inflammatory Response
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription From RNA Polymerase II Promoter
Apoptotic Process
Inflammatory Response
Response To Oxidative Stress
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Lipid Storage
Negative Regulation Of Calcidiol 1-monooxygenase Activity
Negative Regulation Of Vitamin D Biosynthetic Process
Membrane Protein Intracellular Domain Proteolysis
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cholesterol Transport
Positive Regulation Of Type I Interferon Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Interleukin-12 Biosynthetic Process
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Response To Copper Ion
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of MiRNA Metabolic Process
Pathways
Signaling by the B Cell Receptor (BCR)
NF-kB is activated and signals survival
Downstream TCR signaling
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
RIP-mediated NFkB activation via ZBP1
Toll Like Receptor TLR6:TLR2 Cascade
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Activated TLR4 signalling
Toll Like Receptor TLR1:TLR2 Cascade
Downstream signaling events of B Cell Receptor (BCR)
FCERI mediated NF-kB activation
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
ZBP1(DAI) mediated induction of type I IFNs
p75NTR signals via NF-kB
Transcriptional regulation of white adipocyte differentiation
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
Innate Immune System
Regulated proteolysis of p75NTR
Signalling by NGF
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
Senescence-Associated Secretory Phenotype (SASP)
Cytokine Signaling in Immune system
p75 NTR receptor-mediated signalling
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Signaling by Interleukins
TCR signaling
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Interleukin-1 processing
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Activation of NF-kappaB in B cells
Fc epsilon receptor (FCERI) signaling
TRAF6 mediated NF-kB activation
Interleukin-1 signaling
Adaptive Immune System
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Thalidomide
Pranlukast
Triflusal
Diseases
GWAS
Multiple sclerosis (
21833088
)
Primary biliary cirrhosis (
23000144
21399635
)
Schizophrenia (treatment refractory) (
22479419
)
Ulcerative colitis (
23128233
)
Protein-Protein Interactions
4 interactors:
EPHB3
NFKB1
TRDMT1
UCHL5
102 interactors:
ABCC2
AR
ATF3
BCL3
BRCA1
BTRC
CDK9
CEBPB
CFLAR
CHUK
COPB2
COPS5
CTNNB1
E2F1
ECSIT
ELF1
ELF3
EP300
ESR1
ETS1
FBXW11
FOS
G3BP2
GLUL
GSK3B
HDAC1
HIF1AN
HMGA1
HMGA2
HMGB1
HSPA4
IKBKB
IKBKG
IL2RA
IRF1
IRF2
IRF8
IRF9
ITGB3BP
KAT5
KLF5
KPNA3
LYL1
MAP3K8
MEN1
MPP6
MTPN
NCOA1
NCOA6
NCOR2
NFKB2
NFKBIA
NFKBIB
NFKBIE
NFKBIZ
NFRKB
NKRF
NOTCH1
NR3C1
NR4A1
PARP1
PCBD1
PDCD11
PELP1
PLD3
PML
PPARG
PPP4C
PRKACA
PSMD10
REL
RELA
RELB
RGS14
RIPK1
RPS3
RSF1
RXRA
SERPINA3
SF1
SIN3A
SP1
SPAG9
SPI1
SPPL2A
SRF
STAT3
STAT6
TAB2
TNFSF11
TNIP1
TNIP2
TP53BP1
TRIP4
TSC22D3
TXN
UBE2D3
UBE2K
UNC5CL
YWHAQ
YY1
ZBTB9
Entrez ID
4798
4790
HPRD ID
01240
01238
Ensembl ID
ENSG00000170322
ENSG00000109320
Uniprot IDs
Q6P4R8
P19838
PDB IDs
3U21
1MDI
1MDJ
1MDK
1NFI
1SVC
2DBF
2O61
3GUT
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Interleukin-12 Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Negative Regulation Of Calcidiol 1-monooxygenase Activity
Positive Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Vitamin D Biosynthetic Process
Telencephalon Development
C-5 Methylation Of Cytosine
Positive Regulation Of MiRNA Metabolic Process
Cellular Response To Nicotine
Regulation Of Calcidiol 1-monooxygenase Activity
Negative Regulation Of Cholesterol Transport
Regulation Of MiRNA Metabolic Process
Forebrain Development
DNA Methylation On Cytosine
Negative Regulation Of Monooxygenase Activity
Dendritic Spine Morphogenesis
Regulation Of Vitamin Metabolic Process
Regulation Of Interleukin-12 Biosynthetic Process
Membrane Protein Intracellular Domain Proteolysis
Corpus Callosum Development
Dendritic Spine Development
Negative Regulation Of Interleukin-12 Production
Cellular Response To Growth Factor Stimulus
Response To Copper Ion
Retinal Ganglion Cell Axon Guidance
Dendritic Spine Organization
Response To Growth Factor
Forebrain Morphogenesis
Regulation Of Catalytic Activity
Negative Regulation Of Steroid Biosynthetic Process
Regulation Of Rac GTPase Activity
Negative Regulation Of Lipid Transport
TRNA Methylation
Lateral Ventricle Development
Axonal Fasciculation
Negative Regulation Of Steroid Metabolic Process
Negative Regulation Of Oxidoreductase Activity
Cellular Response To Interleukin-6
Response To Organic Substance
Regulation Of Cdc42 GTPase Activity
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cdc42 Protein Signal Transduction
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Response To Interleukin-6
Positive Regulation Of Synapse Assembly
Positive Regulation Of Lipid Storage
Membrane Protein Proteolysis
Response To Amphetamine
Regulation Of Signal Transduction
Brain Development
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Cellular Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Response To Stress
Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Response To Organic Substance
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Cellular Metabolic Process
Cellular Response To Organic Substance
Response To Stimulus
Nucleobase-containing Compound Metabolic Process
Cellular Response To Stimulus
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Intracellular Receptor Signaling Pathway
Heterocycle Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Cellular Response To Stress
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Defense Response
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Immune System Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cellular Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Signal Transduction
Cell Communication
Tagcloud
?
30min
ancestry
asks
asleep
habitual
ifng
ifngr1
il10
il13
il17a
il1b
il1r2
il2
il4
il6
il8
interleukins
nfkb2
pittsburgh
rs1143623
rs1143642
rs1295686
rs2857602
rs4648110
rs4719714
soi
strengthens
tnfa
transgender
Tagcloud (Difference)
?
30min
ancestry
asks
asleep
habitual
ifng
ifngr1
il10
il13
il17a
il1b
il1r2
il2
il4
il6
il8
interleukins
nfkb2
pittsburgh
rs1143623
rs1143642
rs1295686
rs2857602
rs4648110
rs4719714
soi
strengthens
tnfa
transgender
Tagcloud (Intersection)
?