NFKBIB and GIT2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NFKBIB	GIT2
Description		NFKB inhibitor beta	GIT ArfGAP 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Focal Adhesion Synapse Presynapse
	Molecular Function	Transcription Coactivator Activity Protein Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	DNA-templated Transcription Inflammatory Response Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Cellular Response To Lipopolysaccharide	Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Synaptic Vesicle Recycling
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	47 interacting genes: ACTG1 ACTN1 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG
Entrez ID		4793	9815
HPRD ID		07260	09779
Ensembl ID		ENSG00000104825	ENSG00000139436
Uniprot IDs		G5E9C2 Q15653	F8VXI9 F8W822 Q14161 Q6FI58
PDB IDs		9CK0
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Complex Non-canonical NF-kappaB Signal Transduction DNA-directed RNA Polymerase Complex Canonical NF-kappaB Signal Transduction Nucleoplasm DNA-directed RNA Polymerase Activity Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Transcription By RNA Polymerase I DNA-templated Transcription Intracellular Signaling Cassette Negative Regulation Of Canonical NF-kappaB Signal Transduction I-kappaB/NF-kappaB Complex Cytosol Regulation Of Intracellular Signal Transduction RNA Polymerase III Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication RRNA Transcription Tumor Necrosis Factor-mediated Signaling Pathway IkappaB Kinase Complex Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Nucleus DNA Binding Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Transferrin Receptor Binding Signal Transduction Involved In Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-binding Transcription Factor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway NF-kappaB P50/p65 Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Cytokine Response To Peptide Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Positive Regulation Of T Cell Receptor Signaling Pathway	Identical Protein Binding Cytosol Regulation Of Supramolecular Fiber Organization Cytoplasm Focal Adhesion Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Ephrin Receptor Signaling Pathway Cell-cell Junction Regulation Of Microtubule Nucleation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Organization Regulation Of Lung Blood Pressure Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament Cytoskeleton Gamma-tubulin Binding Actin Filament-based Process Response To Type II Interferon Regulation Of Intracellular Signal Transduction Ruffle Positive Regulation Of Microtubule Nucleation Regulation Of Canonical NF-kappaB Signal Transduction Postsynapse Organization Extracellular Exosome Cytoskeleton Organization Regulation Of Organelle Organization Profilin Binding Signal Transduction Thioesterase Binding Neuron Fate Determination Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Organelle Organization Vinculin Binding Regulation Of Programmed Cell Death Ameboidal-type Cell Migration Regulation Of Toll-like Receptor 3 Signaling Pathway Cell Surface Receptor Signaling Pathway Immunological Synapse Formation
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