NFKBIB and NKIRAS2

Number of citations of the paper that reports this interaction (PubMedID 10657303)
0

Data Source:
HPRD (in vitro, in vivo)

		NFKBIB	NKIRAS2
Description		NFKB inhibitor beta	NFKB inhibitor interacting Ras like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GTPase Activating Protein Binding
	Biological Process	DNA-templated Transcription Inflammatory Response Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Cellular Response To Lipopolysaccharide	Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ral Protein Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Surfactant Homeostasis Lung Alveolus Development
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation	RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	5 interacting genes: NFKBIA NFKBIB PAX6 SMN1 TK1
Entrez ID		4793	28511
HPRD ID		07260	07261
Ensembl ID		ENSG00000104825	ENSG00000168256
Uniprot IDs		G5E9C2 Q15653	Q9NYR9
PDB IDs		9CK0
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Complex Non-canonical NF-kappaB Signal Transduction DNA-directed RNA Polymerase Complex Canonical NF-kappaB Signal Transduction Nucleoplasm DNA-directed RNA Polymerase Activity Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Transcription By RNA Polymerase I DNA-templated Transcription Intracellular Signaling Cassette Negative Regulation Of Canonical NF-kappaB Signal Transduction I-kappaB/NF-kappaB Complex Cytosol Regulation Of Intracellular Signal Transduction RNA Polymerase III Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication RRNA Transcription Tumor Necrosis Factor-mediated Signaling Pathway IkappaB Kinase Complex Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Nucleus DNA Binding Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Transferrin Receptor Binding Signal Transduction Involved In Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-binding Transcription Factor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway NF-kappaB P50/p65 Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Cytokine Response To Peptide Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Positive Regulation Of T Cell Receptor Signaling Pathway	Nucleobase-containing Compound Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Macromolecule Biosynthetic Process Forebrain-midbrain Boundary Formation Pancreatic A Cell Development I-kappaB/NF-kappaB Complex Nucleic Acid Metabolic Process Habenula Development Pallium Development DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Forebrain Dorsal/ventral Pattern Formation Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification Formation Of Anatomical Boundary Glial Cell Fate Specification Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization Thymidine Metabolic Process Thymidine Biosynthetic Process Nucleobase-containing Compound Metabolic Process Forebrain Neuron Fate Commitment Ventral Spinal Cord Development Iris Morphogenesis Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cytosol Type B Pancreatic Cell Differentiation HMG Box Domain Binding Co-SMAD Binding Regulation Of Timing Of Cell Differentiation Cornea Development In Camera-type Eye Salivary Gland Morphogenesis Negative Regulation Of Neuroblast Proliferation SMN Complex Gemini Of Cajal Bodies Pyrimidine Nucleoside Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Cellular Response To Cold Dorsal/ventral Axis Specification Regulation Of Development, Heterochronic Embryonic Camera-type Eye Morphogenesis Enteroendocrine Cell Differentiation
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