NFKBIB and BTBD6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NFKBIB	BTBD6
Description		NFKB inhibitor beta	BTB domain containing 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding	Protein Binding
	Biological Process	DNA-templated Transcription Inflammatory Response Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Cellular Response To Lipopolysaccharide	Neurogenesis
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	10 interacting genes: BTBD3 CUL3 DAXX FXR1 GRSF1 NFKBIB NME7 NTAQ1 PAXIP1 TCEA2
Entrez ID		4793	90135
HPRD ID		07260	12540
Ensembl ID		ENSG00000104825	ENSG00000184887
Uniprot IDs		G5E9C2 Q15653	A0A384NYR4 A0A8C8KHP4 Q96KE9
PDB IDs		9CK0	2VKP
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Complex Non-canonical NF-kappaB Signal Transduction DNA-directed RNA Polymerase Complex Canonical NF-kappaB Signal Transduction Nucleoplasm DNA-directed RNA Polymerase Activity Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Transcription By RNA Polymerase I DNA-templated Transcription Intracellular Signaling Cassette Negative Regulation Of Canonical NF-kappaB Signal Transduction I-kappaB/NF-kappaB Complex Cytosol Regulation Of Intracellular Signal Transduction RNA Polymerase III Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication RRNA Transcription Tumor Necrosis Factor-mediated Signaling Pathway IkappaB Kinase Complex Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Nucleus DNA Binding Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Transferrin Receptor Binding Signal Transduction Involved In Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-binding Transcription Factor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway NF-kappaB P50/p65 Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Cytokine Response To Peptide Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Positive Regulation Of T Cell Receptor Signaling Pathway	Ribonucleoprotein Granule Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Molecular Condensate Scaffold Activity Nucleic Acid Metabolic Process Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of RNA Metabolic Process Nucleus Cellular Response To Diamide Nucleobase-containing Compound Catabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Rho Protein Signal Transduction Trophectodermal Cellular Morphogenesis Liver Morphogenesis Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Protein Catabolic Process At Postsynapse Positive Regulation Of Protein Ubiquitination Chorion Development Positive Regulation Of RNA Metabolic Process
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