NFKBIB and NKIRAS1

Number of citations of the paper that reports this interaction (PubMedID 10657303)
0

Data Source:
HPRD (in vitro, in vivo)

		NFKBIB	NKIRAS1
Description		NFKB inhibitor beta	NFKB inhibitor interacting Ras like 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding	Nucleotide Binding GTPase Activity GTP Binding GTPase Activating Protein Binding
	Biological Process	DNA-templated Transcription Inflammatory Response Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Cellular Response To Lipopolysaccharide	Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ral Protein Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Surfactant Homeostasis Lung Alveolus Development
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation	RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435)
Interacting Genes		43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	8 interacting genes: ACVR1 APP BMPR1B NFKBIA NFKBIB SMURF2 TGFBR1 XRCC2
Entrez ID		4793	28512
HPRD ID		07260	06841
Ensembl ID		ENSG00000104825	ENSG00000197885
Uniprot IDs		G5E9C2 Q15653	Q9NYS0
PDB IDs		9CK0
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Complex Non-canonical NF-kappaB Signal Transduction DNA-directed RNA Polymerase Complex Canonical NF-kappaB Signal Transduction Nucleoplasm DNA-directed RNA Polymerase Activity Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Transcription By RNA Polymerase I DNA-templated Transcription Intracellular Signaling Cassette Negative Regulation Of Canonical NF-kappaB Signal Transduction I-kappaB/NF-kappaB Complex Cytosol Regulation Of Intracellular Signal Transduction RNA Polymerase III Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication RRNA Transcription Tumor Necrosis Factor-mediated Signaling Pathway IkappaB Kinase Complex Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Nucleus DNA Binding Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Transferrin Receptor Binding Signal Transduction Involved In Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-binding Transcription Factor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway NF-kappaB P50/p65 Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Cytokine Response To Peptide Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Positive Regulation Of T Cell Receptor Signaling Pathway	Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus BMP Receptor Activity Activin Receptor Complex Positive Regulation Of Developmental Process Activin Receptor Activity, Type I Regionalization Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Response To Growth Factor Regulation Of Developmental Process Activin Binding Regulation Of Cell Differentiation Pattern Specification Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Pharyngeal System Development Positive Regulation Of RNA Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Transforming Growth Factor Beta Binding Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Inflammatory Response Regulation Of Cell Communication Positive Regulation Of Cell Migration Activin Receptor Signaling Pathway Regulation Of RNA Metabolic Process Cellular Response To BMP Stimulus Positive Regulation Of Cell Motility Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signaling Receptor Complex Positive Regulation Of Locomotion Membrane Raft Reproductive Process Defense Response Regulation Of Nucleobase-containing Compound Metabolic Process Ventricular Septum Morphogenesis In Utero Embryonic Development
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