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NFKBIA and COPS8
Number of citations of the paper that reports this interaction (PubMedID
17318178
)
33
Data Source:
HPRD
(in vivo)
NFKBIA
COPS8
Description
NFKB inhibitor alpha
COP9 signalosome subunit 8
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
COP9 Signalosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Protein Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Protein Sequestering Activity
Transcription Regulator Inhibitor Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Inflammatory Response
Notch Signaling Pathway
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Signal Transduction Involved In Regulation Of Gene Expression
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Cholesterol Transport
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Protein Deneddylation
Protein Phosphorylation
Activation Of NF-kappaB-inducing Kinase Activity
Negative Regulation Of Cell Population Proliferation
COP9 Signalosome Assembly
Protein Neddylation
Regulation Of Protein Neddylation
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
SARS-CoV-1 activates/modulates innate immune responses
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Drugs
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Diseases
Hodgkin lymphoma
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
GWAS
Appendicular lean mass (
33097823
)
Asthma (
32296059
30929738
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte count (
32888494
27863252
)
PR interval (
32439900
)
Psoriasis (
20953190
25903422
25854761
25574825
23143594
20953189
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
30578418
27841878
)
Rheumatoid arthritis (
32723749
)
Systolic blood pressure (
28739976
27841878
30578418
)
White blood cell count (
32888494
)
Asthma (
27611488
)
Body mass index (
25673413
)
Coronary artery disease (
33020668
)
Lung cancer (
28604730
)
Motion sickness (
25628336
)
Pulse pressure (
27841878
)
Systemic lupus erythematosus (
19838195
)
Interacting Genes
92 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
UBE2M
UBE2S
USP39
VCP
ZNF212
17 interacting genes:
COPS2
COPS3
COPS4
COPS5
COPS6
COPS7A
CUL1
CUL5
EIF3E
GPS1
ITPK1
MAPRE1
NFKBIA
SUOX
TP53
UBC
USHBP1
Entrez ID
4792
10920
HPRD ID
01235
16737
Ensembl ID
ENSG00000100906
ENSG00000198612
Uniprot IDs
P25963
Q99627
PDB IDs
1IKN
1NFI
6TTU
6Y1J
4D10
4D18
4WSN
6R6H
6R7F
6R7H
6R7I
6R7N
8H38
8H3A
8H3F
Enriched GO Terms of Interacting Partners
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Regulation Of Canonical NF-kappaB Signal Transduction
Nucleoplasm
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Cytosol
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Regulation Of Metabolic Process
Canonical NF-kappaB Signal Transduction
Macromolecule Metabolic Process
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
ATP Binding
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Modification-dependent Protein Catabolic Process
Protein Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Signal Transduction
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Negative Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Intracellular Signaling Cassette
Negative Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Protein Modification By Small Protein Conjugation
Protein Kinase Activity
Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Macromolecule Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Protein Deneddylation
Regulation Of Protein Neddylation
Protein Neddylation
COP9 Signalosome
Protein Modification By Small Protein Removal
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Protein Modification Process
Cytosol
Regulation Of Protein Modification Process
Ubiquitin Protein Ligase Binding
DeNEDDylase Activity
Ubiquitin Ligase Complex Scaffold Activity
Protein Metabolic Process
Metal-dependent Deubiquitinase Activity
Positive Regulation Of T Cell Apoptotic Process
Eukaryotic Translation Initiation Factor 3 Complex
Necroptotic Process
Cullin-RING Ubiquitin Ligase Complex
Positive Regulation Of Lymphocyte Apoptotic Process
Nucleoplasm
Programmed Necrotic Cell Death
T Cell Apoptotic Process
Positive Regulation Of Leukocyte Apoptotic Process
Lymphocyte Apoptotic Process
Cytoplasm
Response To Methotrexate
Inositol-3,4,5,6-tetrakisphosphate 1-kinase Activity
Inositol-1,3,4-trisphosphate 6-kinase Activity
Inositol-3,4,6-trisphosphate 1-kinase Activity
Inositol-1,3,4-trisphosphate 5-kinase Activity
Regulatory T Cell Apoptotic Process
Negative Regulation Of Tolerance Induction
Regulation Of T Cell Apoptotic Process
Sulfite Oxidase Activity
Negative Regulation Of Helicase Activity
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of G1 To G0 Transition
Protein Localization To Astral Microtubule
Protein-containing Complex
Leukocyte Apoptotic Process
Translation Initiation Factor Activity
Dihydrofolate Reductase Activity
Macromolecule Metabolic Process
Eukaryotic Translation Initiation Factor 3 Complex, EIF3e
Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity
Tumor Necrosis Factor-mediated Signaling Pathway
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