NFKBIA and CAPN2

Number of citations of the paper that reports this interaction (PMID 9873017)
34

Data Source:
HPRD (in vitro)

		NFKBIA	CAPN2
Gene Name		nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	calpain 2, (m/II) large subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex	Chromatin Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Dendrite Cortical Actin Cytoskeleton Pseudopodium Membrane Raft Extracellular Vesicular Exosome Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Transcription Factor Binding Nuclear Localization Sequence Binding Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Identical Protein Binding NF-kappaB Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cysteine-type Peptidase Activity Protein Heterodimerization Activity
	Biological Process	Protein Import Into Nucleus, Translocation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Viral Process Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Cell Proliferation Regulation Of NF-kappaB Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Apoptotic Process Response To Exogenous DsRNA Negative Regulation Of DNA Binding Innate Immune Response Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Protein Autoprocessing Regulation Of Cytoskeleton Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Amino Acid Stimulus
Pathways		Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Psoriasis ( 20953189 20953190)
Protein-Protein Interactions		87 interactors: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKAP IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PTPN1 PTPN13 RBX1 REL RELA RNF7 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO2 SUMO3 SUMO4 TBK1 TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2L3 VCP ZNF212	17 interactors: ADRBK1 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 F2RL1 GAS2 KNG1 MAPK1 MAPT NFKBIA NMT1 PTPN1 PTPRN TNS1
Entrez ID		4792	824
HPRD ID		01235	00254
Ensembl ID		ENSG00000100906	ENSG00000162909
Uniprot IDs		P25963	B4DN77 P17655 Q59EF6
PDB IDs		1IKN 1NFI	1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signal Transduction Cellular Response To Stimulus Negative Regulation Of Cell Death Cellular Metabolic Process Toll-like Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Cellular Process Signaling Intracellular Signal Transduction Immune Response Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Cell Death Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Activation Of Innate Immune Response Innate Immune Response Negative Regulation Of Apoptotic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Immune System Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Gene Expression Response To Growth Factor Regulation Of Cytokine Production Response To Stress Regulation Of Nitrogen Compound Metabolic Process Regulation Of Immune Response	Regulation Of Cellular Localization Regulation Of Intracellular Transport Positive Regulation Of Transport Peptidyl-threonine Phosphorylation Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Innate Immune Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Peptidyl-serine Phosphorylation Defense Response Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway Glial Cell Apoptotic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Localization Response To Estrogen Neurotrophin TRK Receptor Signaling Pathway Response To Steroid Hormone Immune Response Neurotrophin Signaling Pathway Response To Lipid Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Intracellular Transport Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Regulation Of Cellular Protein Metabolic Process Response To Stress Establishment Of Localization In Cell Pons Development Response To Hormone Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Mitochondrion Organization Protein Metabolic Process Renal System Process G-protein Coupled Acetylcholine Receptor Signaling Pathway
Tagcloud ?		1alpha advance aggressiveness biopsies cd31 collectively december dehydrogenase demands deregulated diffuse doi enhancing enzymes gapdh glyceraldehyde glycolytic hif hodgkin inactive leu lymphoma lymphomagenesis online promote publication traf2 transformed vascularization	1h basilar camk2a camk2b capn1 cisplatin cochlea deacetylases ganglion hair hdacs immunocytochemistry label neurofilament neurotransmitter newborn organotypic ototoxicity panther phalloidin rab3b rhodamine sgns snap25 spiral tnfrsf1a trichostatin tsa vglut1
Tagcloud (Difference) ?		1alpha advance aggressiveness biopsies cd31 collectively december dehydrogenase demands deregulated diffuse doi enhancing enzymes gapdh glyceraldehyde glycolytic hif hodgkin inactive leu lymphoma lymphomagenesis online promote publication traf2 transformed vascularization	1h basilar camk2a camk2b capn1 cisplatin cochlea deacetylases ganglion hair hdacs immunocytochemistry label neurofilament neurotransmitter newborn organotypic ototoxicity panther phalloidin rab3b rhodamine sgns snap25 spiral tnfrsf1a trichostatin tsa vglut1
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