NFKBIA and ITPK1

Number of citations of the paper that reports this interaction (PubMedID 12324474)
0

Data Source:
BioGRID (enzymatic study)

		NFKBIA	ITPK1
Description		NFKB inhibitor alpha	inositol-tetrakisphosphate 1-kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex	Cytosol Apical Plasma Membrane
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding NF-kappaB Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity	Nucleotide Binding Magnesium Ion Binding Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity Catalytic Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Isomerase Activity Metal Ion Binding Inositol-3,4,5,6-tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Inflammatory Response Notch Signaling Pathway Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Signal Transduction Involved In Regulation Of Gene Expression Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cholesterol Transport Response To Muramyl Dipeptide Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Muscle Stretch Non-canonical NF-kappaB Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response B Cell Receptor Signaling Pathway Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cytokine Production Involved In Inflammatory Response	Signal Transduction Blood Coagulation Neural Tube Development Inositol Trisphosphate Metabolic Process Necroptotic Process
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation SUMOylation of immune response proteins IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling Ub-specific processing proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation SARS-CoV-1 activates/modulates innate immune responses Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Synthesis of pyrophosphates in the cytosol Synthesis of IP3 and IP4 in the cytosol Factors involved in megakaryocyte development and platelet production
Drugs		Acetylsalicylic acid Bardoxolone methyl Astaxanthin
Diseases		Hodgkin lymphoma Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
GWAS		Appendicular lean mass ( 33097823) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Creatine kinase levels ( 29403010) Eczema ( 31361310) Hip circumference adjusted for BMI ( 25673412) Inflammatory skin disease ( 25574825) Lymphocyte count ( 32888494 27863252) PR interval ( 32439900) Psoriasis ( 20953190 25903422 25854761 25574825 23143594 20953189) Psoriasis vulgaris ( 26626624) Pulse pressure ( 30578418 27841878) Rheumatoid arthritis ( 32723749) Systolic blood pressure ( 28739976 27841878 30578418) White blood cell count ( 32888494)	Body mass index ( 26426971) Chronic obstructive pulmonary disease ( 30804561) Endometriosis ( 23472165) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Migraine ( 27182965 27322543) Monocyte count ( 32888494) Platelet count ( 22139419 32888494) Plateletcrit ( 27863252 32888494) Spleen volume ( 34128465) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)
Interacting Genes		92 interacting genes: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 ELP1 ENKD1 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MAP3K7 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PSMD3 PTPN1 PTPN13 REL RELA RNF115 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO4 TBK1 TCL1A TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2L3 UBE2M UBE2S USP39 VCP ZNF212	6 interacting genes: COPS8 GPS1 JUN NFKBIA TP53 TRAF2
Entrez ID		4792	3705
HPRD ID		01235	03501
Ensembl ID		ENSG00000100906	ENSG00000100605
Uniprot IDs		P25963	G3V4M9 Q13572
PDB IDs		1IKN 1NFI 6TTU 6Y1J	2ODT 2Q7D 2QB5 9DN3
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Protein Modification Process Cytosol Nucleus Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Canonical NF-kappaB Signal Transduction Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process ATP Binding Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Modification-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Nucleotide Binding Intracellular Signaling Cassette Negative Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Cell Communication Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation Protein Kinase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process	Intracellular Signaling Cassette Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Ubiquitin Protein Ligase Binding Tumor Necrosis Factor-mediated Signaling Pathway Enzyme Binding Protein Deneddylation General Transcription Initiation Factor Binding Regulation Of Protein Neddylation Protein Neddylation Programmed Necrotic Cell Death Response To Muscle Stretch COP9 Signalosome Response To Endoplasmic Reticulum Stress Non-canonical NF-kappaB Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Nucleoplasm Positive Regulation Of MiRNA Transcription JNK Cascade Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Cytokine-mediated Signaling Pathway Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition TORC2 Complex Disassembly Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Leukocyte Activation Positive Regulation Of Apoptotic Process Leading Edge Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Oligodendrocyte Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Protein Import Into Nucleus Regulation Of Protein Modification Process
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