NFKBIA and TUBA1B

Number of citations of the paper that reports this interaction (PMID 9372968)
25

Data Source:
HPRD (in vivo)

		NFKBIA	TUBA1B
Gene Name		nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	tubulin, alpha 1b
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex	Microtubule Cytoplasmic Microtubule Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding Nuclear Localization Sequence Binding Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Identical Protein Binding NF-kappaB Binding	Double-stranded RNA Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Import Into Nucleus, Translocation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Viral Process Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Cell Proliferation Regulation Of NF-kappaB Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Apoptotic Process Response To Exogenous DsRNA Negative Regulation Of DNA Binding Innate Immune Response Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway	Microtubule Cytoskeleton Organization Protein Folding Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division Cellular Response To Interleukin-4
Pathways		Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs			Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS		Psoriasis ( 20953189 20953190)
Protein-Protein Interactions		87 interactors: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKAP IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PTPN1 PTPN13 RBX1 REL RELA RNF7 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO2 SUMO3 SUMO4 TBK1 TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2L3 VCP ZNF212	27 interactors: A2M AGTRAP CCT2 EPN2 ESR1 FYN GRM7 GZMM HDAC6 MAPT MINK1 MTCL1 MYC NFKBIA PFDN5 PIK3R1 PSEN1 PTP4A1 PXN SIAH1 SLX1B SMAD2 SNAP91 TERT TMEM253 TOM1L1 TUBG1
Entrez ID		4792	10376
HPRD ID		01235	03960
Ensembl ID		ENSG00000100906	ENSG00000123416
Uniprot IDs		P25963	P68363
PDB IDs		1IKN 1NFI	2E4H
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signal Transduction Cellular Response To Stimulus Negative Regulation Of Cell Death Cellular Metabolic Process Toll-like Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Cellular Process Signaling Intracellular Signal Transduction Immune Response Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Cell Death Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Activation Of Innate Immune Response Innate Immune Response Negative Regulation Of Apoptotic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Immune System Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Gene Expression Response To Growth Factor Regulation Of Cytokine Production Response To Stress Regulation Of Nitrogen Compound Metabolic Process Regulation Of Immune Response	Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Response To Growth Factor T Cell Receptor Signaling Pathway Negative Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Regulation Of Catalytic Activity Response To Stress Regulation Of Cell Death Negative Regulation Of Signaling Cellular Protein Complex Assembly Cellular Response To Growth Factor Stimulus Cell Communication Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Stimulus Cellular Response To Stimulus Response To DsRNA Programmed Cell Death Regulation Of Metabolic Process Tube Morphogenesis Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Cell Death Death Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Regulation Of Microtubule-based Movement Regulation Of Cell Morphogenesis Developmental Process Cellular Response To Stress Regulation Of Cell Differentiation Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Transport Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Organelle Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Receptor Activity Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Signal Transduction Negative Regulation Of Programmed Cell Death Growth Hormone Receptor Signaling Pathway
Tagcloud ?		1alpha advance aggressiveness biopsies cd31 collectively december dehydrogenase demands deregulated diffuse doi enhancing enzymes gapdh glyceraldehyde glycolytic hif hodgkin inactive leu lymphoma lymphomagenesis online promote publication traf2 transformed vascularization	accounts annotation aurora bad bub1 cdc2 cdc25 cebpb cgh compact correlating delineated e2f1 exceptions explorative exploratory gepat hallmark hodgkin implicates incurable mantle mcl proliferative refine socs1 tight wee1 wilcoxon
Tagcloud (Difference) ?		1alpha advance aggressiveness biopsies cd31 collectively december dehydrogenase demands deregulated diffuse doi enhancing enzymes gapdh glyceraldehyde glycolytic hif inactive leu lymphoma lymphomagenesis online promote publication traf2 transformed vascularization	accounts annotation aurora bad bub1 cdc2 cdc25 cebpb cgh compact correlating delineated e2f1 exceptions explorative exploratory gepat hallmark implicates incurable mantle mcl proliferative refine socs1 tight wee1 wilcoxon
Tagcloud (Intersection) ?		hodgkin