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NFKBIA and TBK1
Number of citations of the paper that reports this interaction (PubMedID
9721103
)
0
Data Source:
HPRD
(in vitro, in vivo)
NFKBIA
TBK1
Description
NFKB inhibitor alpha
TANK binding kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Nucleoplasm
Cytoplasm
Cytosol
Serine/threonine Protein Kinase Complex
Molecular Function
Protein Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Protein Sequestering Activity
Transcription Regulator Inhibitor Activity
Nucleotide Binding
Nucleic Acid Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Phosphatase Binding
Identical Protein Binding
Phosphoprotein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Inflammatory Response
Notch Signaling Pathway
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Signal Transduction Involved In Regulation Of Gene Expression
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Cholesterol Transport
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Cytoplasmic Translation
Activation Of Innate Immune Response
Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Protein Phosphorylation
Protein Import Into Nucleus
Inflammatory Response
Canonical NF-kappaB Signal Transduction
MRNA Transcription
Response To Virus
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Macroautophagy
Positive Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Metabolic Process
Signal Transduction Involved In Regulation Of Gene Expression
Cellular Response To Nutrient Levels
Positive Regulation Of TOR Signaling
Regulation Of Type I Interferon Production
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Toll-like Receptor 4 Signaling Pathway
TORC1 Signaling
TORC2 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Dendritic Cell Proliferation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Translational Initiation
Defense Response To Gram-positive Bacterium
Defense Response To Virus
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
T Follicular Helper Cell Differentiation
Defense Response To Other Organism
Antiviral Innate Immune Response
CGAS/STING Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Xenophagy
Positive Regulation Of TORC2 Signaling
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
SARS-CoV-1 activates/modulates innate immune responses
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
PINK1-PRKN Mediated Mitophagy
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
Interleukin-37 signaling
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
Potential therapeutics for SARS
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Fostamatinib
Diseases
Hodgkin lymphoma
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
GWAS
Appendicular lean mass (
33097823
)
Asthma (
32296059
30929738
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte count (
32888494
27863252
)
PR interval (
32439900
)
Psoriasis (
20953190
25903422
25854761
25574825
23143594
20953189
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
30578418
27841878
)
Rheumatoid arthritis (
32723749
)
Systolic blood pressure (
28739976
27841878
30578418
)
White blood cell count (
32888494
)
Amyotrophic lateral sclerosis (
27455348
29566793
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Lung adenocarcinoma (
28604730
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
92 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
UBE2M
UBE2S
USP39
VCP
ZNF212
47 interacting genes:
AGO2
APP
ATG9A
AZI2
CDC20
CDC37
CDC42BPG
CRTC1
CYLD
FZR1
HSP90AA1
HSP90AB1
IKBKB
IKBKG
IRF3
IRF5
IRF7
LMO7
MAVS
MBP
MIB2
MTPAP
NCK1
NFKBIA
PROS1
PTPRD
RELA
RIPK1
RNF128
RPS6KB1
SIKE1
SMCR8
SMURF1
STX11
TANK
TICAM1
TNIP1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRIM21
TXLNG
UBC
UBQLN2
VHL
XIAP
Entrez ID
4792
29110
HPRD ID
01235
05322
Ensembl ID
ENSG00000100906
ENSG00000183735
Uniprot IDs
P25963
Q9UHD2
PDB IDs
1IKN
1NFI
6TTU
6Y1J
4EFO
4EUT
4EUU
4IM0
4IM2
4IM3
4IW0
4IWO
4IWP
4IWQ
5EOA
5EOF
5EP6
5W5V
6BNY
6BOD
6BOE
6CQ0
6CQ4
6CQ5
6NT9
6O8B
6RSR
6RST
6RSU
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Nucleoplasm
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Cytosol
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Regulation Of Metabolic Process
Canonical NF-kappaB Signal Transduction
Macromolecule Metabolic Process
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
ATP Binding
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Modification-dependent Protein Catabolic Process
Protein Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Signal Transduction
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Negative Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Intracellular Signaling Cassette
Negative Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Protein Modification By Small Protein Conjugation
Protein Kinase Activity
Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Macromolecule Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Type I Interferon Production
Positive Regulation Of Metabolic Process
Activation Of Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Regulation Of Cytokine Production
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response-activating Signaling Pathway
Regulation Of Immune Response
Regulation Of Innate Immune Response
Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Signal Transduction
Cytokine-mediated Signaling Pathway
Activation Of Immune Response
Immune Response-activating Signaling Pathway
Defense Response
Regulation Of Protein Metabolic Process
Positive Regulation Of Defense Response
Positive Regulation Of Innate Immune Response
Regulation Of Cell Communication
Positive Regulation Of Type I Interferon Production
Regulation Of DNA-binding Transcription Factor Activity
Canonical NF-kappaB Signal Transduction
Regulation Of Interferon-beta Production
Response To Virus
Tumor Necrosis Factor-mediated Signaling Pathway
Response To External Biotic Stimulus
Cytosol
Immune Response-regulating Signaling Pathway
Signal Transduction Involved In Regulation Of Gene Expression
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Defense Response
Regulation Of Intracellular Signal Transduction
Response To Other Organism
Regulation Of Immune System Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Immune Response
Signaling Adaptor Activity
Cytoplasm
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cytokine Production
Protein Ubiquitination
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Tagcloud (Intersection)
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