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NFKBIA and IKBKE
Number of citations of the paper that reports this interaction (PubMedID
10421793
)
0
Data Source:
HPRD
(in vitro)
NFKBIA
IKBKE
Description
NFKB inhibitor alpha
inhibitor of nuclear factor kappa B kinase subunit epsilon
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Mitochondrial Membrane
Serine/threonine Protein Kinase Complex
Molecular Function
Protein Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Protein Sequestering Activity
Transcription Regulator Inhibitor Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
K48-linked Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Inflammatory Response
Notch Signaling Pathway
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Signal Transduction Involved In Regulation Of Gene Expression
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Cholesterol Transport
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Activation Of Innate Immune Response
Response To Stress
Immune Response
DNA Damage Response
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Gene Expression
Positive Regulation Of Lipid Storage
Positive Regulation Of Type I Interferon Production
Response To Cytokine
Response To Type I Interferon
Response To Interferon-beta
Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein-containing Complex Assembly
MRNA Stabilization
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Interleukin-17-mediated Signaling Pathway
Cellular Response To Virus
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
SARS-CoV-1 activates/modulates innate immune responses
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
SUMOylation of immune response proteins
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Fostamatinib
Diseases
Hodgkin lymphoma
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
GWAS
Appendicular lean mass (
33097823
)
Asthma (
32296059
30929738
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte count (
32888494
27863252
)
PR interval (
32439900
)
Psoriasis (
20953190
25903422
25854761
25574825
23143594
20953189
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
30578418
27841878
)
Rheumatoid arthritis (
32723749
)
Systolic blood pressure (
28739976
27841878
30578418
)
White blood cell count (
32888494
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Metabolite levels (
23823483
)
Psoriasis (
28537254
)
Systemic lupus erythematosus (
27399966
33272962
)
Interacting Genes
92 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
UBE2M
UBE2S
USP39
VCP
ZNF212
22 interacting genes:
AZI2
BIRC2
BIRC3
CDC37
CHUK
CYLD
DDX3X
FKBP5
HSP90AA1
HSP90AB1
IRF3
IRF5
KTN1
MBP
NFKBIA
RELA
RIPK1
SIKE1
TANK
TICAM1
TRIM27
XIAP
Entrez ID
4792
9641
HPRD ID
01235
05442
Ensembl ID
ENSG00000100906
ENSG00000263528
Uniprot IDs
P25963
A0A075B7B4
Q14164
PDB IDs
1IKN
1NFI
6TTU
6Y1J
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Nucleoplasm
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Cytosol
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Regulation Of Metabolic Process
Canonical NF-kappaB Signal Transduction
Macromolecule Metabolic Process
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
ATP Binding
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Modification-dependent Protein Catabolic Process
Protein Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Signal Transduction
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Negative Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Intracellular Signaling Cassette
Negative Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Protein Modification By Small Protein Conjugation
Protein Kinase Activity
Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Macromolecule Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Regulation Of Innate Immune Response
Regulation Of Canonical NF-kappaB Signal Transduction
Canonical NF-kappaB Signal Transduction
Regulation Of Cytokine Production
Positive Regulation Of Cytokine Production
Activation Of Innate Immune Response
Regulation Of Post-translational Protein Modification
Regulation Of Defense Response
Pattern Recognition Receptor Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Response To External Biotic Stimulus
Innate Immune Response-activating Signaling Pathway
Cytokine-mediated Signaling Pathway
Positive Regulation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Receptor Signaling Pathway
Regulation Of Protein Modification Process
Positive Regulation Of Metabolic Process
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Response To Stress
Response To Virus
Regulation Of Apoptotic Process
Regulation Of Immune Response
Activation Of Immune Response
Regulation Of Programmed Cell Death
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Gene Expression
Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Non-canonical NF-kappaB Signal Transduction
Defense Response
Immune Response-activating Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Response To Other Organism
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Positive Regulation Of Interferon-beta Production
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Intracellular Signal Transduction
Immune Response-regulating Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Canonical NF-kappaB Signal Transduction
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Tagcloud (Intersection)
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