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NFKBIA and REL
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
NFKBIA
REL
Description
NFKB inhibitor alpha
REL proto-oncogene, NF-kB subunit
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
NF-kappaB Complex
Molecular Function
Protein Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Protein Sequestering Activity
Transcription Regulator Inhibitor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Inflammatory Response
Notch Signaling Pathway
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Signal Transduction Involved In Regulation Of Gene Expression
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Cholesterol Transport
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Cytokine Production
Regulation Of DNA-templated Transcription
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Negative Regulation Of Gene Expression
Negative Regulation Of Interferon-beta Production
Response To Cytokine
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
SARS-CoV-1 activates/modulates innate immune responses
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Activation of NF-kappaB in B cells
Drugs
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Diseases
Hodgkin lymphoma
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Hodgkin lymphoma
GWAS
Appendicular lean mass (
33097823
)
Asthma (
32296059
30929738
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte count (
32888494
27863252
)
PR interval (
32439900
)
Psoriasis (
20953190
25903422
25854761
25574825
23143594
20953189
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
30578418
27841878
)
Rheumatoid arthritis (
32723749
)
Systolic blood pressure (
28739976
27841878
30578418
)
White blood cell count (
32888494
)
Celiac disease (
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
22412388
21102463
)
Erectile dysfunction (
30583798
)
Hodgkin's lymphoma (
21037568
24920014
)
Inflammatory bowel disease (
23128233
)
Psoriasis (
20953190
23143594
25574825
25903422
)
Psoriasis vulgaris (
26626624
)
Psoriatic arthritis (
22170493
26626624
)
Rheumatoid arthritis (
19503088
30423114
24390342
23143596
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Ulcerative colitis (
20228799
)
Interacting Genes
92 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
UBE2M
UBE2S
USP39
VCP
ZNF212
319 interacting genes:
A1CF
AAAS
ACBD4
ACOT12
ACOT8
ACTN3
ADRB2
ADSL
AGPAT4
AIRIM
AKT2
ALOX5
AQP1
AR
ARFIP2
ARIH2
ARL16
ARMC7
ARNT2
ASAP3
ASMTL
ATG9A
ATP6V0D2
ATP6V1C2
ATPAF2
ATXN1
BANP
BARHL2
BBS4
BCL2L15
BCL6
BID
BLTP2
BMF
C11orf68
C12orf75
C14orf119
C1orf50
C1orf56
C1orf74
C9orf72
CABP5
CACNA1S
CALM1
CCNC
CCNE1
CCNJL
CDK18
CDKN1A
CDKN2C
CDKN2D
CDR2L
CENPX
CEP19
CFAP206
CGGBP1
CHAF1A
CHCHD2
CHIC2
CIB3
CINP
CKS1B
CLIC4
CLIP1
COL20A1
COL8A1
CPNE2
CPNE7
CPSF1
CSNK2A1
CTNNA3
CTNNBIP1
CXCL14
CYB5R2
DAAM2
DDX6
DEF6
DGCR6
DHPS
DMRT3
DNTT
DPF2
DYNC1LI1
EFHC1
EHHADH
EIF3A
EIF3D
EIF4A3
EIF4E2
EIF4EBP1
EIF5A
EIF5A2
ELF1
EMD
EML2
EP300
EPHB6
EPM2AIP1
ESRRA
ESRRG
EXOSC1
EXOSC5
EXOSC8
FAAP20
FAM200C
FAM90A1
FHIT
FHL2
FKBP1B
FLAD1
FLNA
FNDC11
FNDC3B
FOXO4
GADD45G
GLYCTK
GPKOW
GRAP
GRB2
GTF2B
HAT1
HDAC7
HIP1
HLA-DOA
HNRNPF
HNRNPLL
HSD17B14
HSPA4
HSPA8
HSPB7
IL36RN
KCTD6
KCTD7
KLHL32
KLHL40
KLHL42
KRTAP9-4
L3MBTL2
LASP1
LENG1
LGALS14
LMO1
LMO2
LNPEP
LSM2
MAD2L2
MAGOHB
MAP3K7CL
MAP3K8
MAPK8
MAPRE3
MB21D2
MBD3
MEMO1
MID2
MIEN1
MIPOL1
MLIP
MMP2
MORF4L1
MORF4L2
MRPL10
MSRB3
MTPN
MTURN
MVP
MYO15B
NABP1
NAGK
NCK2
NDE1
NDUFAF3
NECAP1
NEDD9
NEIL2
NEUROG3
NFE2L2
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NGB
NKRF
NME7
NMRK1
NOL9
NOTCH1
NOXA1
NR2C2AP
NUCB1
NUDT10
NUDT14
NXT2
OAZ3
OSGIN1
OSTF1
OTUB2
OTUD4
PADI3
PAK1IP1
PARVG
PATE1
PCYT2
PELI2
PGAP6
PICK1
PIH1D2
PLCB4
PLEKHN1
PM20D2
POFUT4
POLE2
POLR2L
POP5
PPP4C
PRDM10
PRKAA2
PRKAB2
PRKN
PRPF31
PSMA1
PSMA4
PSMB8
PSORS1C2
PTGER3
PTK6
QARS1
R3HDM2
RAB29
RAB41
RABIF
RAD23A
RAD51D
RASSF5
RBM39
RECK
RELA
REXO1L6P
RIPPLY1
RNF213
RNF6
RSPH14
RTL8C
RUNX1T1
S100A1
SAMD11
SAT1
SCNM1
SDCBP
SEC14L4
SEC31A
SEPTIN7
SHC3
SIN3A
SIX1
SLC39A13
SLC41A3
SLC6A12
SMG9
SNRNP25
SP1
SPATC1L
SPG21
SPRY1
SRF
STAMBPL1
STK16
SULT2B1
SUOX
SZT2
TBC1D21
TBC1D22B
TBP
TCL1A
TCP11L1
TDO2
THOC1
TLE5
TLX3
TMEM165
TMEM268
TNIP2
TNS2
TRAPPC2L
TRAPPC6A
TRIM27
TRIM68
TRIM74
TSC22D3
TSEN15
TSPOAP1
TSSC4
TSSK3
TSTD2
TTC19
TTC21A
TXNL4B
UBASH3A
UBASH3B
UBE2D4
UBE2K
UBE2Z
UBXN7
VPS25
WNK3
YARS1
YJU2
ZBTB16
ZDHHC24
ZIC1
ZNF417
ZNF446
ZNF550
ZNF564
ZNF572
ZNF688
ZNF76
ZNF765
Entrez ID
4792
5966
HPRD ID
01235
01286
Ensembl ID
ENSG00000100906
ENSG00000162924
Uniprot IDs
P25963
A0A8V8TPL7
Q04864
PDB IDs
1IKN
1NFI
6TTU
6Y1J
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Nucleoplasm
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Cytosol
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Regulation Of Metabolic Process
Canonical NF-kappaB Signal Transduction
Macromolecule Metabolic Process
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
ATP Binding
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Modification-dependent Protein Catabolic Process
Protein Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Signal Transduction
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Negative Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Intracellular Signaling Cassette
Negative Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Protein Modification By Small Protein Conjugation
Protein Kinase Activity
Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Macromolecule Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Protein Binding
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Identical Protein Binding
Nucleic Acid Metabolic Process
I-kappaB/NF-kappaB Complex
Nucleobase-containing Compound Metabolic Process
DNA-binding Transcription Factor Binding
Macromolecule Metabolic Process
Spliceosomal Complex
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein K6-linked Ubiquitination
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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