NFKBIA and UBE2S

Number of citations of the paper that reports this interaction (PubMedID 34582005)
0

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		NFKBIA	UBE2S
Description		NFKB inhibitor alpha	ubiquitin conjugating enzyme E2 S
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding NF-kappaB Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Inflammatory Response Notch Signaling Pathway Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Signal Transduction Involved In Regulation Of Gene Expression Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cholesterol Transport Response To Muramyl Dipeptide Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Muscle Stretch Non-canonical NF-kappaB Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response B Cell Receptor Signaling Pathway Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cytokine Production Involved In Inflammatory Response	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K29-linked Ubiquitination Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation SUMOylation of immune response proteins IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling Ub-specific processing proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation SARS-CoV-1 activates/modulates innate immune responses Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Acetylsalicylic acid Bardoxolone methyl Astaxanthin
Diseases		Hodgkin lymphoma Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
GWAS		Appendicular lean mass ( 33097823) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Creatine kinase levels ( 29403010) Eczema ( 31361310) Hip circumference adjusted for BMI ( 25673412) Inflammatory skin disease ( 25574825) Lymphocyte count ( 32888494 27863252) PR interval ( 32439900) Psoriasis ( 20953190 25903422 25854761 25574825 23143594 20953189) Psoriasis vulgaris ( 26626624) Pulse pressure ( 30578418 27841878) Rheumatoid arthritis ( 32723749) Systolic blood pressure ( 28739976 27841878 30578418) White blood cell count ( 32888494)
Interacting Genes		92 interacting genes: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 ELP1 ENKD1 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MAP3K7 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PSMD3 PTPN1 PTPN13 REL RELA RNF115 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO4 TBK1 TCL1A TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2L3 UBE2M UBE2S USP39 VCP ZNF212	33 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CYLD HECTD3 HERC1 LINC00839 MDM2 NFKBIA OTUB1 OTUD7B PRKN RBCK1 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP2 USP21 USP5 USP7
Entrez ID		4792	27338
HPRD ID		01235	15603
Ensembl ID		ENSG00000100906	ENSG00000108106
Uniprot IDs		P25963	Q16763
PDB IDs		1IKN 1NFI 6TTU 6Y1J	1ZDN 5BNB 5L9T 6QH3 6QHK 6S96 6S98 7AHF 8TAU
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Protein Modification Process Cytosol Nucleus Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Canonical NF-kappaB Signal Transduction Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process ATP Binding Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Modification-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Nucleotide Binding Intracellular Signaling Cassette Negative Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Cell Communication Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation Protein Kinase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process	Post-translational Protein Modification Proteolysis Protein Modification Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Protein Deubiquitination Proteasomal Protein Catabolic Process Protein Modification By Small Protein Removal Protein Catabolic Process Protein Branched Polyubiquitination Protein Polyubiquitination Macromolecule Metabolic Process Catabolic Process Regulation Of Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cysteine-type Deubiquitinase Activity Protein K48-linked Ubiquitination Regulation Of Sister Chromatid Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Cytosol Positive Regulation Of Mitotic Sister Chromatid Separation Cysteine-type Peptidase Activity Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Chromosome Organization Positive Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Phase Transition Regulation Of Reproductive Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Metaphase/anaphase Transition Of Cell Cycle Ubiquitin Binding Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Separation Peptidase Activity Regulation Of Mitotic Cell Cycle Phase Transition
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