NCK1 and BRK1

Number of citations of the paper that reports this interaction (PMID 8605018)
19

Data Source:
HPRD (in vivo, in vitro)

		NCK1	BRK1
Gene Name		NCK adaptor protein 1	BRICK1, SCAR/WAVE actin-nucleating complex subunit
Image
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Plasma Membrane Cell-cell Junction Vesicle Membrane	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Receptor Binding Protein Binding Cytoskeletal Adaptor Activity Protein Domain Specific Binding Receptor Signaling Complex Scaffold Activity Protein Binding, Bridging Receptor Tyrosine Kinase Binding Eukaryotic Initiation Factor EIF2 Binding	Protein Complex Binding Rac GTPase Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Signal Complex Assembly Axon Guidance Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Response To Other Organism Negative Regulation Of Cell Death Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	In Utero Embryonic Development Positive Regulation Of Cell Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Protein Homotrimerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Signaling by PDGF Signaling by the B Cell Receptor (BCR) Generation of second messenger molecules Axon guidance DCC mediated attractive signaling VEGFA-VEGFR2 Pathway TCR signaling Activation of Rac Signaling by VEGF Downstream signal transduction Nephrin interactions Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		76 interactors: ABI1 ABL1 ADAM15 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CRK CSNK1G2 CYFIP2 DAG1 DCC DNM1 DOK1 DOK2 DRD3 DRD4 EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB3 FASLG FGFR1 FLT1 FLT3 FRS2 GAB2 KDR KHDRBS1 KIAA1522 LCP2 LPHN2 MAP4K1 MAP4K4 MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NPHS1 NTRK2 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SHANK3 SOCS1 SOCS7 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1	6 interactors: CYFIP2 DTNBP1 NCK1 NCKAP1 PFDN1 WASF1
Entrez ID		4690	55845
HPRD ID		02740	12818
Ensembl ID		ENSG00000158092	ENSG00000254999
Uniprot IDs		P16333	Q8WUW1
PDB IDs		2CI8 2CI9 2CUB 2JS0 2JS2 2JW4	3P8C
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Autophosphorylation Immune Response Regulation Of Catalytic Activity Regulation Of Immune System Process Defense Response Locomotion Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Chemotaxis Axon Guidance Cell Morphogenesis Involved In Differentiation Positive Regulation Of Immune Response Positive Regulation Of Kinase Activity Regulation Of Cellular Process Cell Morphogenesis Involved In Neuron Differentiation Cell Development	Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Nucleation Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Lamellipodium Assembly Lamellipodium Organization Regulation Of Actin Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Vesicle-mediated Transport Movement Of Cell Or Subcellular Component Organelle Organization Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Translation In Response To Stress Basal Protein Localization Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Establishment Or Maintenance Of Actin Cytoskeleton Polarity Positive Regulation Of Cytoplasmic Translation Innate Immune Response Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Immune System Process Regulation Of Immune Response Zygotic Determination Of Anterior/posterior Axis, Embryo Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Nervous System Development Ras Protein Signal Transduction Regulation Of Dopamine Receptor Signaling Pathway
Tagcloud ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	aberrantly anaphase assembling benzimidazole bub1 centromeric chromatids correcting diakinesis faithfully h2a homologs kinetochore kinetochores meiosis merotelic metaphase oryza precocious ps10 pt134 sativa shugoshin1 sister speculate sterile synchronicity uncorrected uninhibited
Tagcloud (Difference) ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	aberrantly anaphase assembling benzimidazole bub1 centromeric chromatids correcting diakinesis faithfully h2a homologs kinetochore kinetochores meiosis merotelic metaphase oryza precocious ps10 pt134 sativa shugoshin1 sister speculate sterile synchronicity uncorrected uninhibited
Tagcloud (Intersection) ?