NCK1 and FRS2

Number of citations of the paper that reports this interaction (PMID 12154000)
4

Data Source:
HPRD (in vitro)

		NCK1	FRS2
Gene Name		NCK adaptor protein 1	fibroblast growth factor receptor substrate 2
Image
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Plasma Membrane Cell-cell Junction Vesicle Membrane	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Membrane
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Receptor Binding Protein Binding Cytoskeletal Adaptor Activity Protein Domain Specific Binding Receptor Signaling Complex Scaffold Activity Protein Binding, Bridging Receptor Tyrosine Kinase Binding Eukaryotic Initiation Factor EIF2 Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Insulin Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phosphatase Activator Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Signal Complex Assembly Axon Guidance Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Response To Other Organism Negative Regulation Of Cell Death Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Activation Of MAPKK Activity Activation Of MAPK Activity Gastrulation With Mouth Forming Second Organ Induction Ventricular Septum Development Epidermal Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Neuroblast Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Development Fc-epsilon Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Optic Placode Formation Involved In Camera-type Eye Formation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Epithelial Cell Proliferation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade
Pathways		Signaling by PDGF Signaling by the B Cell Receptor (BCR) Generation of second messenger molecules Axon guidance DCC mediated attractive signaling VEGFA-VEGFR2 Pathway TCR signaling Activation of Rac Signaling by VEGF Downstream signal transduction Nephrin interactions Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Signalling to ERKs Prolonged ERK activation events IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS			Height ( 20881960 23563607 18391951) Response to diuretic therapy ( 18591461)
Protein-Protein Interactions		76 interactors: ABI1 ABL1 ADAM15 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CRK CSNK1G2 CYFIP2 DAG1 DCC DNM1 DOK1 DOK2 DRD3 DRD4 EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB3 FASLG FGFR1 FLT1 FLT3 FRS2 GAB2 KDR KHDRBS1 KIAA1522 LCP2 LPHN2 MAP4K1 MAP4K4 MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NPHS1 NTRK2 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SHANK3 SOCS1 SOCS7 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1	22 interactors: CBL CRK DDR1 FGFR1 GAB1 GRB2 INSR KDR MAPK1 NCK1 NTRK1 NTRK2 NTRK3 PAK1 PRKCI PRKCZ PTPN11 PTPRF RET RND1 SOS1 SRC
Entrez ID		4690	10818
HPRD ID		02740	06372
Ensembl ID		ENSG00000158092	ENSG00000166225
Uniprot IDs		P16333	L7RTG7 Q8WU20
PDB IDs		2CI8 2CI9 2CUB 2JS0 2JS2 2JW4	1XR0
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Autophosphorylation Immune Response Regulation Of Catalytic Activity Regulation Of Immune System Process Defense Response Locomotion Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Chemotaxis Axon Guidance Cell Morphogenesis Involved In Differentiation Positive Regulation Of Immune Response Positive Regulation Of Kinase Activity Regulation Of Cellular Process Cell Morphogenesis Involved In Neuron Differentiation Cell Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Locomotion Cellular Response To Insulin Stimulus Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Neurotrophin Signaling Pathway Movement Of Cell Or Subcellular Component Response To Insulin Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cell Migration Cellular Response To Peptide Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Cell Motility Cellular Response To Organic Substance Response To Peptide Hormone Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Peptide Insulin Receptor Signaling Pathway Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Neuron Development Regulation Of Phosphorylation Response To Organic Substance Activation Of Protein Kinase Activity Cellular Response To Hormone Stimulus Fc Receptor Signaling Pathway Signaling Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Protein Autophosphorylation Positive Regulation Of Kinase Activity Generation Of Neurons
Tagcloud ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	adapter adenoviruses bdnf branching cascades cortical docking facilitates fgf frs3 gab1 gab2 goals grb2 impairs multiprotein neurite neurotrophic neurotrophin neurotrophins outgrowth phosphatidylinositide pi3 route shp2 stimulates trk twofold utilize
Tagcloud (Difference) ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	adapter adenoviruses bdnf branching cascades cortical docking facilitates fgf frs3 gab1 gab2 goals grb2 impairs multiprotein neurite neurotrophic neurotrophin neurotrophins outgrowth phosphatidylinositide pi3 route shp2 stimulates trk twofold utilize
Tagcloud (Intersection) ?