NCK1 and DRD4

Number of citations of the paper that reports this interaction (PMID 9843378)
16

Data Source:
HPRD (in vivo)

		NCK1	DRD4
Gene Name		NCK adaptor protein 1	dopamine receptor D4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Plasma Membrane Cell-cell Junction Vesicle Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Vesicle Membrane Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Receptor Binding Protein Binding Cytoskeletal Adaptor Activity Protein Domain Specific Binding Receptor Signaling Complex Scaffold Activity Protein Binding, Bridging Receptor Tyrosine Kinase Binding Eukaryotic Initiation Factor EIF2 Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity Protein Binding Drug Binding Potassium Channel Regulator Activity SH3 Domain Binding Dopamine Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Signal Complex Assembly Axon Guidance Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Response To Other Organism Negative Regulation Of Cell Death Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Activation Of MAPK Activity Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Cellular Calcium Ion Homeostasis Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Short-term Memory Circadian Rhythm Adult Locomotory Behavior Olfactory Learning Photoperiodism Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Kinase Activity Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Regulation Of Neurotransmitter Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Response To Steroid Hormone Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Regulation Of Calcium-mediated Signaling Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Penile Erection Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Signaling by PDGF Signaling by the B Cell Receptor (BCR) Generation of second messenger molecules Axon guidance DCC mediated attractive signaling VEGFA-VEGFR2 Pathway TCR signaling Activation of Rac Signaling by VEGF Downstream signal transduction Nephrin interactions Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs			Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Thiethylperazine Remoxipride Pramipexole Promazine Lisuride Apomorphine Risperidone Propiomazine Dopamine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Iloperidone Rotigotine Asenapine
Diseases
GWAS
Protein-Protein Interactions		76 interactors: ABI1 ABL1 ADAM15 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CRK CSNK1G2 CYFIP2 DAG1 DCC DNM1 DOK1 DOK2 DRD3 DRD4 EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB3 FASLG FGFR1 FLT1 FLT3 FRS2 GAB2 KDR KHDRBS1 KIAA1522 LCP2 LPHN2 MAP4K1 MAP4K4 MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NPHS1 NTRK2 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SHANK3 SOCS1 SOCS7 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1	6 interactors: CLIC6 GABRA1 GRB2 KCNJ9 KLHL12 NCK1
Entrez ID		4690	1815
HPRD ID		02740	00541
Ensembl ID		ENSG00000158092	ENSG00000069696
Uniprot IDs		P16333	P21917
PDB IDs		2CI8 2CI9 2CUB 2JS0 2JS2 2JW4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Autophosphorylation Immune Response Regulation Of Catalytic Activity Regulation Of Immune System Process Defense Response Locomotion Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Chemotaxis Axon Guidance Cell Morphogenesis Involved In Differentiation Positive Regulation Of Immune Response Positive Regulation Of Kinase Activity Regulation Of Cellular Process Cell Morphogenesis Involved In Neuron Differentiation Cell Development	Transport Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Actin Filament Polymerization Chloride Transmembrane Transport Positive Regulation Of Protein Polymerization Chloride Transport Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Cell-cell Signaling Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Complex Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Signal Transduction Inorganic Anion Transport Phagocytosis Cellular Response To Histamine Synaptic Transmission, GABAergic Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of T Cell Activation Positive Regulation Of Cell Activation Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Cellular Component Biogenesis Response To Histamine Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytoplasmic Translation Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Ion Transmembrane Transport Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation
Tagcloud ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	adhd cleft clefting collect conceptual dat1 disabilities disruptive dopamine drd2 familial genotyped heritability hyperactivity impulse inattention inattentive neurobehavioral ofc orofacial overlap pilot polymorphisms proposing restlessness saliva stressors taq1a1 warranted
Tagcloud (Difference) ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	adhd cleft clefting collect conceptual dat1 disabilities disruptive dopamine drd2 familial genotyped heritability hyperactivity impulse inattention inattentive neurobehavioral ofc orofacial overlap pilot polymorphisms proposing restlessness saliva stressors taq1a1 warranted
Tagcloud (Intersection) ?