NCK1 and PDGFRB

Number of citations of the paper that reports this interaction (PMID 1333047)
41

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		NCK1	PDGFRB
Gene Name		NCK adaptor protein 1	platelet-derived growth factor receptor, beta polypeptide
Image
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Plasma Membrane Cell-cell Junction Vesicle Membrane	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Apical Plasma Membrane Intrinsic Component Of Plasma Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Receptor Binding Protein Binding Cytoskeletal Adaptor Activity Protein Domain Specific Binding Receptor Signaling Complex Scaffold Activity Protein Binding, Bridging Receptor Tyrosine Kinase Binding Eukaryotic Initiation Factor EIF2 Binding	Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Phosphatidylinositol 3-kinase Binding Platelet-derived Growth Factor Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Signal Complex Assembly Axon Guidance Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Response To Other Organism Negative Regulation Of Cell Death Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	In Utero Embryonic Development Tissue Homeostasis Glycosaminoglycan Biosynthetic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Adrenal Gland Development Positive Regulation Of Cell Migration Response To Estradiol Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Retinoic Acid Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Response To Fluid Shear Stress Cell Migration Involved In Vasculogenesis Metanephric Mesenchymal Cell Migration Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Mitotic Nuclear Division Phosphatidylinositol Metabolic Process Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Smooth Muscle Tissue Development Inner Ear Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Chemotaxis Cardiac Myofibril Assembly Response To Hyperoxia Cell Chemotaxis Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Mesenchyme Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process
Pathways		Signaling by PDGF Signaling by the B Cell Receptor (BCR) Generation of second messenger molecules Axon guidance DCC mediated attractive signaling VEGFA-VEGFR2 Pathway TCR signaling Activation of Rac Signaling by VEGF Downstream signal transduction Nephrin interactions Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Becaplermin Sorafenib Imatinib Dasatinib Sunitinib Pazopanib Regorafenib
Diseases
GWAS
Protein-Protein Interactions		76 interactors: ABI1 ABL1 ADAM15 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CRK CSNK1G2 CYFIP2 DAG1 DCC DNM1 DOK1 DOK2 DRD3 DRD4 EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB3 FASLG FGFR1 FLT1 FLT3 FRS2 GAB2 KDR KHDRBS1 KIAA1522 LCP2 LPHN2 MAP4K1 MAP4K4 MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NPHS1 NTRK2 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SHANK3 SOCS1 SOCS7 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1	59 interactors: ARAF BAG1 CAV1 CAV3 CBL COPA COPB1 CRK EGFR EIF2AK2 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 JAK1 JAK2 KLHL12 KRTAP4-12 NCK1 NCK2 NEDD4 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCG1 PRDX2 PTK2 PTPN1 PTPN11 PTPN2 PTPRJ RAF1 RASA1 S1PR1 SHC1 SLC9A3R1 SNX1 SNX2 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TRIP6 TYK2 VAV1 YES1
Entrez ID		4690	5159
HPRD ID		02740	01423
Ensembl ID		ENSG00000158092	ENSG00000113721
Uniprot IDs		P16333	P09619 Q59F04
PDB IDs		2CI8 2CI9 2CUB 2JS0 2JS2 2JW4	1GQ5 1H9O 1LWP 2L6W 2PLD 2PLE 3MJG
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Autophosphorylation Immune Response Regulation Of Catalytic Activity Regulation Of Immune System Process Defense Response Locomotion Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Chemotaxis Axon Guidance Cell Morphogenesis Involved In Differentiation Positive Regulation Of Immune Response Positive Regulation Of Kinase Activity Regulation Of Cellular Process Cell Morphogenesis Involved In Neuron Differentiation Cell Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Signal Transduction Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Body Fluid Levels Regulation Of Immune System Process Response To Peptide Hormone Signal Transduction Regulation Of Immune Response Response To Peptide Blood Coagulation Hemostasis Regulation Of Phosphorus Metabolic Process Signaling Cell Communication Innate Immune Response Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Regulation Of Kinase Activity Wound Healing Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Signal Transduction Locomotion Positive Regulation Of Signal Transduction Response To Wounding Cell Migration Fibroblast Growth Factor Receptor Signaling Pathway Response To Hormone Neurotrophin TRK Receptor Signaling Pathway Defense Response Neurotrophin Signaling Pathway Leukocyte Migration Cell Motility Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Protein Phosphorylation Response To Organic Substance
Tagcloud ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	14q32 5q31 5q33 apart apl aspirate break complication cytogenetic cytogenetics exon firstly fusion infrequent kiaa1509 myeloid neoplasm neoplasms partner promyelocytic q32 q33 rara rarely rearrangement rt trip11 undetectable xy
Tagcloud (Difference) ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	14q32 5q31 5q33 apart apl aspirate break complication cytogenetic cytogenetics exon firstly fusion infrequent kiaa1509 myeloid neoplasm neoplasms partner promyelocytic q32 q33 rara rarely rearrangement rt trip11 undetectable xy
Tagcloud (Intersection) ?