NCK1 and LPHN2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NCK1	LPHN2
Gene Name		NCK adaptor protein 1	latrophilin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Plasma Membrane Cell-cell Junction Vesicle Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Receptor Binding Protein Binding Cytoskeletal Adaptor Activity Protein Domain Specific Binding Receptor Signaling Complex Scaffold Activity Protein Binding, Bridging Receptor Tyrosine Kinase Binding Eukaryotic Initiation Factor EIF2 Binding	G-protein Coupled Receptor Activity Latrotoxin Receptor Activity Carbohydrate Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Signal Complex Assembly Axon Guidance Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Response To Other Organism Negative Regulation Of Cell Death Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	G-protein Coupled Receptor Signaling Pathway
Pathways		Signaling by PDGF Signaling by the B Cell Receptor (BCR) Generation of second messenger molecules Axon guidance DCC mediated attractive signaling VEGFA-VEGFR2 Pathway TCR signaling Activation of Rac Signaling by VEGF Downstream signal transduction Nephrin interactions Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Temperament ( 22832960)
Protein-Protein Interactions		76 interactors: ABI1 ABL1 ADAM15 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CRK CSNK1G2 CYFIP2 DAG1 DCC DNM1 DOK1 DOK2 DRD3 DRD4 EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB3 FASLG FGFR1 FLT1 FLT3 FRS2 GAB2 KDR KHDRBS1 KIAA1522 LCP2 LPHN2 MAP4K1 MAP4K4 MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NPHS1 NTRK2 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SHANK3 SOCS1 SOCS7 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1	3 interactors: NCK1 SHANK1 SHANK2
Entrez ID		4690	23266
HPRD ID		02740	06116
Ensembl ID		ENSG00000158092	ENSG00000117114
Uniprot IDs		P16333	O95490
PDB IDs		2CI8 2CI9 2CUB 2JS0 2JS2 2JW4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Autophosphorylation Immune Response Regulation Of Catalytic Activity Regulation Of Immune System Process Defense Response Locomotion Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Chemotaxis Axon Guidance Cell Morphogenesis Involved In Differentiation Positive Regulation Of Immune Response Positive Regulation Of Kinase Activity Regulation Of Cellular Process Cell Morphogenesis Involved In Neuron Differentiation Cell Development	Vocalization Behavior Social Behavior Memory Learning Determination Of Affect Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Adult Behavior Synapse Organization Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Peptidyl-serine Dephosphorylation Habituation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Sensory Processing Learning Or Memory Cognition Cellular Component Assembly Nonassociative Learning Regulation Of Actin Cytoskeleton Organization Righting Reflex Synapse Maturation Regulation Of Actin Filament-based Process Nervous System Development Olfactory Behavior Single-organism Behavior Substrate-dependent Cell Migration, Cell Extension Regulation Of Cytoplasmic Translation Regulation Of Cytoskeleton Organization Cytoskeletal Anchoring At Plasma Membrane Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Dendritic Spine Morphogenesis Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Translational Initiation Signal Complex Assembly Cell Morphogenesis Involved In Neuron Differentiation Behavior Chemosensory Behavior Regulation Of Translation In Response To Stress Long Term Synaptic Depression Neuron Projection Morphogenesis Dendritic Spine Development Regulation Of Signaling Protein Localization To Synapse Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Reflex Dendritic Spine Organization Cell Morphogenesis Involved In Differentiation
Tagcloud ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 missense pard6b pde4c pias2 proline prpf40a pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic
Tagcloud (Difference) ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 missense pard6b pde4c pias2 proline prpf40a pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic
Tagcloud (Intersection) ?