NCK1 and CAV2

Number of citations of the paper that reports this interaction (PMID 12091389)
16

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		NCK1	CAV2
Gene Name		NCK adaptor protein 1	caveolin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Plasma Membrane Cell-cell Junction Vesicle Membrane	Golgi Membrane Acrosomal Membrane Intracellular Nucleus Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Membrane Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Receptor Binding Protein Binding Cytoskeletal Adaptor Activity Protein Domain Specific Binding Receptor Signaling Complex Scaffold Activity Protein Binding, Bridging Receptor Tyrosine Kinase Binding Eukaryotic Initiation Factor EIF2 Binding	Protein Binding D1 Dopamine Receptor Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Signal Complex Assembly Axon Guidance Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Response To Other Organism Negative Regulation Of Cell Death Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Vesicle Fusion Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Mitotic Nuclear Division Insulin Receptor Signaling Pathway Vesicle Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Vesicle Docking Skeletal Muscle Fiber Development Protein Oligomerization Positive Regulation Of Dopamine Receptor Signaling Pathway Caveola Assembly
Pathways		Signaling by PDGF Signaling by the B Cell Receptor (BCR) Generation of second messenger molecules Axon guidance DCC mediated attractive signaling VEGFA-VEGFR2 Pathway TCR signaling Activation of Rac Signaling by VEGF Downstream signal transduction Nephrin interactions Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Glaucoma (primary open-angle) ( 20835238) PR interval ( 20062060)
Protein-Protein Interactions		76 interactors: ABI1 ABL1 ADAM15 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CRK CSNK1G2 CYFIP2 DAG1 DCC DNM1 DOK1 DOK2 DRD3 DRD4 EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB3 FASLG FGFR1 FLT1 FLT3 FRS2 GAB2 KDR KHDRBS1 KIAA1522 LCP2 LPHN2 MAP4K1 MAP4K4 MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NPHS1 NTRK2 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SHANK3 SOCS1 SOCS7 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1	11 interactors: CAV1 CSNK2A1 DNAJA1 DRD1 EGFR FLOT2 GOLGB1 MALL NCK1 RASA1 SRC
Entrez ID		4690	858
HPRD ID		02740	03029
Ensembl ID		ENSG00000158092	ENSG00000105971
Uniprot IDs		P16333	P51636 Q53X57
PDB IDs		2CI8 2CI9 2CUB 2JS0 2JS2 2JW4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Autophosphorylation Immune Response Regulation Of Catalytic Activity Regulation Of Immune System Process Defense Response Locomotion Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Chemotaxis Axon Guidance Cell Morphogenesis Involved In Differentiation Positive Regulation Of Immune Response Positive Regulation Of Kinase Activity Regulation Of Cellular Process Cell Morphogenesis Involved In Neuron Differentiation Cell Development	Locomotion Negative Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Negative Regulation Of Cell Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Axon Guidance Regulation Of Apoptotic Process Cell Motility Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Neuron Development Axonogenesis Axon Development Negative Regulation Of Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation Response To External Stimulus Chemotaxis Neuron Differentiation Neuron Projection Morphogenesis Regulation Of MAP Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Negative Regulation Of Anoikis Signal Complex Assembly Regulation Of Phosphorus Metabolic Process Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Intracellular Signal Transduction Generation Of Neurons Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Anoikis Regulation Of Intracellular Transport Neurogenesis Astrocyte Development Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Intrinsic Apoptotic Signaling Pathway Gland Morphogenesis
Tagcloud ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	3tau alpha1 alpha1b alpha2delta altogether auxiliary ba2 cavbeta channels clamp closer coexpression construct excitable facilitated gated mysterious physiology pore pscm138 pscm174 recording retained traffic trafficked tsa unidentified voltage
Tagcloud (Difference) ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	3tau alpha1 alpha1b alpha2delta altogether auxiliary ba2 cavbeta channels clamp closer coexpression construct excitable facilitated gated mysterious physiology pore pscm138 pscm174 recording retained traffic trafficked tsa unidentified voltage
Tagcloud (Intersection) ?