NCK1 and MAP4K4

Number of citations of the paper that reports this interaction (PMID 9135144)
46

Data Source:
HPRD (in vivo, in vitro)

		NCK1	MAP4K4
Gene Name		NCK adaptor protein 1	mitogen-activated protein kinase kinase kinase kinase 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Plasma Membrane Cell-cell Junction Vesicle Membrane	Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Receptor Binding Protein Binding Cytoskeletal Adaptor Activity Protein Domain Specific Binding Receptor Signaling Complex Scaffold Activity Protein Binding, Bridging Receptor Tyrosine Kinase Binding Eukaryotic Initiation Factor EIF2 Binding	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Signal Complex Assembly Axon Guidance Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Response To Other Organism Negative Regulation Of Cell Death Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Protein Phosphorylation Signal Transduction By Phosphorylation Microvillus Assembly Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Catalytic Activity
Pathways		Signaling by PDGF Signaling by the B Cell Receptor (BCR) Generation of second messenger molecules Axon guidance DCC mediated attractive signaling VEGFA-VEGFR2 Pathway TCR signaling Activation of Rac Signaling by VEGF Downstream signal transduction Nephrin interactions Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Protein-Protein Interactions		76 interactors: ABI1 ABL1 ADAM15 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CRK CSNK1G2 CYFIP2 DAG1 DCC DNM1 DOK1 DOK2 DRD3 DRD4 EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB3 FASLG FGFR1 FLT1 FLT3 FRS2 GAB2 KDR KHDRBS1 KIAA1522 LCP2 LPHN2 MAP4K1 MAP4K4 MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NPHS1 NTRK2 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SHANK3 SOCS1 SOCS7 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1	18 interactors: BRCA1 CASP8 DOK1 GBP3 HIST2H2BE ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2
Entrez ID		4690	9448
HPRD ID		02740	05235
Ensembl ID		ENSG00000158092	ENSG00000071054
Uniprot IDs		P16333	B7Z3V5 O95819
PDB IDs		2CI8 2CI9 2CUB 2JS0 2JS2 2JW4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Autophosphorylation Immune Response Regulation Of Catalytic Activity Regulation Of Immune System Process Defense Response Locomotion Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Chemotaxis Axon Guidance Cell Morphogenesis Involved In Differentiation Positive Regulation Of Immune Response Positive Regulation Of Kinase Activity Regulation Of Cellular Process Cell Morphogenesis Involved In Neuron Differentiation Cell Development	Response To External Stimulus Regulation Of Cell Adhesion Multicellular Organismal Development Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Developmental Process Signaling Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Response To Stimulus Cellular Response To Organic Substance Anatomical Structure Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Death Regulation Of Apoptotic Process System Development Positive Regulation Of Cell Adhesion Regulation Of Cell Death Signal Transduction Response To Abiotic Stimulus Response To Other Organism Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Adhesion Cell Projection Organization Response To Biotic Stimulus Nervous System Development Cellular Response To Mechanical Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Toll-like Receptor 4 Signaling Pathway Defense Response Response To Organic Substance Axonogenesis Regulation Of Organelle Organization Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Cell Death Axon Development Negative Regulation Of Necrotic Cell Death Response To Stress Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Necroptotic Process Movement Of Cell Or Subcellular Component
Tagcloud ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis
Tagcloud (Difference) ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis
Tagcloud (Intersection) ?