NCK1 and KDR

Number of citations of the paper that reports this interaction (PMID 9405464)
62

Data Source:
HPRD (in vitro, in vivo)

		NCK1	KDR
Gene Name		NCK adaptor protein 1	kinase insert domain receptor
Image
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Plasma Membrane Cell-cell Junction Vesicle Membrane	Extracellular Region Nucleus Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Membrane Raft Sorting Endosome
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Receptor Binding Protein Binding Cytoskeletal Adaptor Activity Protein Domain Specific Binding Receptor Signaling Complex Scaffold Activity Protein Binding, Bridging Receptor Tyrosine Kinase Binding Eukaryotic Initiation Factor EIF2 Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Integrin Binding Protein Binding ATP Binding Growth Factor Binding Vascular Endothelial Growth Factor Binding Hsp90 Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Signal Complex Assembly Axon Guidance Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Response To Other Organism Negative Regulation Of Cell Death Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Angiogenesis Ovarian Follicle Development Vasculogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Mesenchymal Cell Proliferation Endothelium Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Extracellular Matrix Organization Positive Regulation Of Cell Migration Embryonic Hemopoiesis Calcium-mediated Signaling Using Intracellular Calcium Source Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Surfactant Homeostasis Positive Regulation Of MAPK Cascade Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Cell Maturation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Focal Adhesion Assembly Calcium Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		Signaling by PDGF Signaling by the B Cell Receptor (BCR) Generation of second messenger molecules Axon guidance DCC mediated attractive signaling VEGFA-VEGFR2 Pathway TCR signaling Activation of Rac Signaling by VEGF Downstream signal transduction Nephrin interactions Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	VEGF binds to VEGFR leading to receptor dimerization EPHA-mediated growth cone collapse VEGF ligand-receptor interactions Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF EPH-Ephrin signaling Neurophilin interactions with VEGF and VEGFR Integrin cell surface interactions VEGFA-VEGFR2 Pathway
Drugs			Sorafenib Sunitinib N-(4-{4-AMINO-6-[4-(METHYLOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-5-YL}PHENYL)-N\'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA Pazopanib Axitinib 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one N\'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Cabozantinib Regorafenib Ponatinib
Diseases
GWAS
Protein-Protein Interactions		76 interactors: ABI1 ABL1 ADAM15 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CRK CSNK1G2 CYFIP2 DAG1 DCC DNM1 DOK1 DOK2 DRD3 DRD4 EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB3 FASLG FGFR1 FLT1 FLT3 FRS2 GAB2 KDR KHDRBS1 KIAA1522 LCP2 LPHN2 MAP4K1 MAP4K4 MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NPHS1 NTRK2 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SHANK3 SOCS1 SOCS7 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1	49 interactors: ACP1 AIMP2 ANXA5 ATR BMX BTRC CAV1 CBL CDH5 COL18A1 CRK CSF2RB CSNK1D CTNNB1 DNM2 FBXO25 FBXW11 FIGF FLT1 FLT4 FRS2 FYN GNA11 GNAQ GRB10 GRB2 HSP90AA1 IQGAP1 ITGB3 NCK1 NRP1 P2RY2 PLCG1 PLCG2 PTPN11 PTPN6 RASA1 SH2D2A SHB SHC1 SHC2 SRC STAT1 SYNGAP1 TIMP3 UBC VEGFA VEGFC YES1
Entrez ID		4690	3791
HPRD ID		02740	01867
Ensembl ID		ENSG00000158092	ENSG00000128052
Uniprot IDs		P16333	P35968
PDB IDs		2CI8 2CI9 2CUB 2JS0 2JS2 2JW4	1VR2 1Y6A 1Y6B 1YWN 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 4AG8 4AGC 4AGD 4ASD 4ASE
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Autophosphorylation Immune Response Regulation Of Catalytic Activity Regulation Of Immune System Process Defense Response Locomotion Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Chemotaxis Axon Guidance Cell Morphogenesis Involved In Differentiation Positive Regulation Of Immune Response Positive Regulation Of Kinase Activity Regulation Of Cellular Process Cell Morphogenesis Involved In Neuron Differentiation Cell Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Body Fluid Levels Response To Growth Factor Anatomical Structure Morphogenesis Response To Wounding Positive Regulation Of Cellular Protein Metabolic Process Wound Healing Platelet Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process System Development Response To Organic Substance Cardiovascular System Development Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Anatomical Structure Development Cell Differentiation Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Leukocyte Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Blood Vessel Development Cellular Response To Peptide Positive Regulation Of Metabolic Process Angiogenesis
Tagcloud ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	accepted aorta cd34 cd45 clustered coexpress embryo emerge flk gata genesis gonad hematogenous hematopoietic library lin mesoderm mesonephros myb para primitive sac sorted strikingly territory therefrom ventral vertebrate yolk
Tagcloud (Difference) ?		adaptor biogenesis biosynthesis compatible delays dephosphorylated dephosphorylation faster homology insulinoma islets juxtamembrane littermates min6 negatively nonphosphorylatable pancreatic perk proinsulin protecting proteostasis py regulates sh2 threonine transmembrane y y561f	accepted aorta cd34 cd45 clustered coexpress embryo emerge flk gata genesis gonad hematogenous hematopoietic library lin mesoderm mesonephros myb para primitive sac sorted strikingly territory therefrom ventral vertebrate yolk
Tagcloud (Intersection) ?