ZFHX3 and COPS6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZFHX3	COPS6
Description		zinc finger homeobox 3	COP9 signalosome subunit 6
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding	Protein Binding Peptidase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Circadian Regulation Of Gene Expression Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Transforming Growth Factor Beta Regulation Of Locomotor Rhythm	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation
Pathways		RUNX3 regulates CDKN1A transcription	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 33990960 29892015 28416822 28416818 19597491 19597492 22544366) Behavioural changes in frontotemporal lobe dementia ( 29724592) Body mass index ( 29273807 28892062) Brain morphology (MOSTest) ( 32665545) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Chronotype ( 30696823) Early onset atrial fibrillation ( 28460022) Estimated glomerular filtration rate ( 31015462 31152163 31451708) General risk tolerance (MTAG) ( 30643258) Glucocorticoid-induced osteonecrosis ( 26265699) Heel bone mineral density ( 30598549) Hypospadias ( 25108383) Incident atrial fibrillation ( 28416818) Ischemic stroke (cardioembolic) ( 26708676) Kawasaki disease ( 19132087) LDL cholesterol ( 21347282) Lung function (FVC) ( 30061609) Metabolite levels ( 22916037 23823483) Morning person ( 30696823) Nose morphology ( 29921221) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Prevalent atrial fibrillation ( 28416818) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sick sinus syndrome ( 33580673) Smoking status (ever vs never smokers) ( 30643258) Stroke (ischemic) ( 23041239) Type 2 diabetes ( 32499647)	Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		36 interacting genes: ALKBH4 AURKA BHLHE40 CEP70 CNOT2 COPS6 CSTPP1 DEUP1 EFHC2 GOLGA2 GOLGA6L9 HIVEP1 KRT31 KRT34 KRT40 LMNB2 MSX2 MTUS2 MYB NINL PIAS3 PIBF1 PICK1 POU2F1 POU6F2 PRPF40A RBM11 SPECC1L TACC1 TLE5 TRIM27 TRIM54 TRIML2 TTC23 USHBP1 ZNF620	95 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CRIPTO CUL1 CUL5 DIS3L2 DLEU1 DSP EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHANK3 SHC3 SLC2A1 SMN1 SNRPG STAMBPL1 STK40 STX5 SULT1E1 TK1 TP53 TP63 TRDMT1 TRIB3 UBC USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24
Entrez ID		463	10980
HPRD ID		00075	16735
Ensembl ID		ENSG00000140836	ENSG00000168090
Uniprot IDs		Q15911 Q8N2Y6	Q7L5N1
PDB IDs		2DA1 2DA2 2DA3	4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cytoskeleton Microtubule Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Mitotic Spindle Organization Microtubule Organizing Center Microtubule Cytoskeleton Organization Involved In Mitosis Structural Constituent Of Skin Epidermis Cilium Disassembly Centrosome Spindle Organization Cell Division Intermediate Filament Meiotic Spindle Assembly Intermediate Filament Organization Organelle Disassembly Microtubule Organizing Center Organization SUMO Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Meiotic Spindle Organization Spindle Assembly Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process	Protein Neddylation Protein Deneddylation Regulation Of Protein Neddylation Nucleoplasm Heart Development COP9 Signalosome Developmental Process Cytosol Cellular Response To Staurosporine Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Protein Binding Positive Regulation Of Neuron Apoptotic Process Protease Binding Pyroptotic Inflammatory Response Protein Modification By Small Protein Removal Nucleus Animal Organ Development Regulation Of Cell Cycle G1/S Phase Transition Cytoplasm Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Developmental Process Cell Differentiation Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Scaffold Protein Binding MAPK Cascade Cellular Response To Alkaloid Regulation Of Protein Modification Process Positive Regulation Of Programmed Cell Death Post-translational Protein Modification Protein Modification Process Regulation Of Post-translational Protein Modification Protein Tag Activity Cullin-RING Ubiquitin Ligase Complex Protein-containing Complex Cellular Response To Starvation Response To Nutrient Levels Mitotic G1 DNA Damage Checkpoint Signaling Rhythmic Synaptic Transmission G1/S Transition Of Mitotic Cell Cycle Mitotic G1/S Transition Checkpoint Signaling
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