ZFHX3 and CNOT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZFHX3	CNOT2
Description		zinc finger homeobox 3	CCR4-NOT transcription complex subunit 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding	Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Circadian Regulation Of Gene Expression Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Transforming Growth Factor Beta Regulation Of Locomotor Rhythm	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Stem Cell Population Maintenance
Pathways		RUNX3 regulates CDKN1A transcription	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 33990960 29892015 28416822 28416818 19597491 19597492 22544366) Behavioural changes in frontotemporal lobe dementia ( 29724592) Body mass index ( 29273807 28892062) Brain morphology (MOSTest) ( 32665545) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Chronotype ( 30696823) Early onset atrial fibrillation ( 28460022) Estimated glomerular filtration rate ( 31015462 31152163 31451708) General risk tolerance (MTAG) ( 30643258) Glucocorticoid-induced osteonecrosis ( 26265699) Heel bone mineral density ( 30598549) Hypospadias ( 25108383) Incident atrial fibrillation ( 28416818) Ischemic stroke (cardioembolic) ( 26708676) Kawasaki disease ( 19132087) LDL cholesterol ( 21347282) Lung function (FVC) ( 30061609) Metabolite levels ( 22916037 23823483) Morning person ( 30696823) Nose morphology ( 29921221) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Prevalent atrial fibrillation ( 28416818) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sick sinus syndrome ( 33580673) Smoking status (ever vs never smokers) ( 30643258) Stroke (ischemic) ( 23041239) Type 2 diabetes ( 32499647)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369) Triglyceride levels ( 32154731)
Interacting Genes		36 interacting genes: ALKBH4 AURKA BHLHE40 CEP70 CNOT2 COPS6 CSTPP1 DEUP1 EFHC2 GOLGA2 GOLGA6L9 HIVEP1 KRT31 KRT34 KRT40 LMNB2 MSX2 MTUS2 MYB NINL PIAS3 PIBF1 PICK1 POU2F1 POU6F2 PRPF40A RBM11 SPECC1L TACC1 TLE5 TRIM27 TRIM54 TRIML2 TTC23 USHBP1 ZNF620	27 interacting genes: ARMC5 BCL6 BEX1 CCHCR1 CFAP68 CIMIP1 CNOT1 CNOT3 CNOT8 CSTF2 DDB1 DSCR9 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 OBI1 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3
Entrez ID		463	4848
HPRD ID		00075	05367
Ensembl ID		ENSG00000140836	ENSG00000111596
Uniprot IDs		Q15911 Q8N2Y6	B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8
PDB IDs		2DA1 2DA2 2DA3	4C0D 4C0F 5FU6 5FU7
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cytoskeleton Microtubule Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Mitotic Spindle Organization Microtubule Organizing Center Microtubule Cytoskeleton Organization Involved In Mitosis Structural Constituent Of Skin Epidermis Cilium Disassembly Centrosome Spindle Organization Cell Division Intermediate Filament Meiotic Spindle Assembly Intermediate Filament Organization Organelle Disassembly Microtubule Organizing Center Organization SUMO Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Meiotic Spindle Organization Spindle Assembly Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process	CCR4-NOT Core Complex CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening Rhythmic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction GTPase Inhibitor Activity Transcription Repressor Complex Poly(A)-specific Ribonuclease Activity RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Trophectodermal Cell Differentiation Negative Regulation Of Androgen Receptor Signaling Pathway Nucleus P-body Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cellular Senescence Regulation Of B Cell Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Axonemal A Tubule Inner Sheath Negative Regulation Of MiRNA Transcription Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of JNK Cascade Cyclin Binding Negative Regulation Of Cardiac Chamber Formation Histone Deacetylase Binding Negative Regulation Of Heart Looping Regulation Of Androgen Receptor Signaling Pathway Regulation Of Brood Size Outer Acrosomal Membrane Adrenal Cortex Development Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process
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