ZFHX3 and SPECC1L

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ZFHX3	SPECC1L
Name		zinc finger homeobox 3	sperm antigen with calponin homology and coiled-coil domains 1 like
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body	Cytoplasm Microtubule Organizing Center Spindle Cytoskeleton Cell-cell Junction Gap Junction Actin Cytoskeleton Microtubule Cytoskeleton Filamentous Actin Anchoring Junction
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding	Protein Binding Beta-catenin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Circadian Regulation Of Gene Expression Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Transforming Growth Factor Beta Regulation Of Locomotor Rhythm	Negative Regulation Of Microtubule Depolymerization Cell Adhesion Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Depolymerization Adherens Junction Organization Neural Crest Cell Delamination Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Anterior Neural Tube Closure
Pathways		RUNX3 regulates CDKN1A transcription	None
GWAS		Atrial fibrillation ( 30061737 33990960 29892015 28416822 28416818 19597491 19597492 22544366 ) Behavioural changes in frontotemporal lobe dementia ( 29724592 ) Body mass index ( 29273807 28892062 ) Brain morphology (MOSTest) ( 32665545 ) Cardioembolic stroke (CCS and TOAST classification) ( 32047268 ) Cardioembolic stroke (CCS or TOAST classification) ( 32047268 ) Cardioembolic stroke (CCSc classification) ( 32047268 ) Cardioembolic stroke (CCSp classification) ( 32047268 ) Cardioembolic stroke (TOAST classification) ( 32047268 ) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697 ) Chronotype ( 30696823 ) Early onset atrial fibrillation ( 28460022 ) Estimated glomerular filtration rate ( 31015462 31152163 31451708 ) General risk tolerance (MTAG) ( 30643258 ) Glucocorticoid-induced osteonecrosis ( 26265699 ) Heel bone mineral density ( 30598549 ) Hypospadias ( 25108383 ) Incident atrial fibrillation ( 28416818 ) Ischemic stroke (cardioembolic) ( 26708676 ) Kawasaki disease ( 19132087 ) LDL cholesterol ( 21347282 ) Lung function (FVC) ( 30061609 ) Metabolite levels ( 22916037 23823483 ) Morning person ( 30696823 ) Nose morphology ( 29921221 ) Number of sexual partners ( 30643258 ) Photic sneeze reflex ( 27182965 ) Prevalent atrial fibrillation ( 28416818 ) Refractive error ( 32231278 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Serum alkaline phosphatase levels ( 33547301 ) Sick sinus syndrome ( 33580673 ) Smoking status (ever vs never smokers) ( 30643258 ) Stroke (ischemic) ( 23041239 ) Type 2 diabetes ( 32499647 )	Acne (severe) ( 24927181 30542056 ) Caffeine consumption from tea ( 33287642 ) Coronary artery disease ( 29212778 32469254 ) Kawasaki disease ( 33692975 ) Mean reticulocyte volume ( 32888494 ) Severity of nausea and vomiting of pregnancy ( 29563502 )
Novel Interactors		1 novel interactors: DYNC1LI2	None recorded
Interacting Genes		36 interacting genes: ALKBH4 AURKA BHLHE40 CEP70 CNOT2 COPS6 CSTPP1 DEUP1 EFHC2 GOLGA2 GOLGA6L9 HIVEP1 KRT31 KRT34 KRT40 LMNB2 MSX2 MTUS2 MYB NINL PIAS3 PIBF1 PICK1 POU2F1 POU6F2 PRPF40A RBM11 SPECC1L TACC1 TLE5 TRIM27 TRIM54 TRIML2 TTC23 USHBP1 ZNF620	11 interacting genes: APC ECPAS EFCAB3 ELOA GLIS2 PPP1R12C SNW1 UBC UBE2I ZFHX3 ZNF250
Entrez ID		463	23384
HPRD ID		00075	11080
Ensembl ID		ENSG00000140836	ENSG00000100014
Uniprot IDs		Q15911 Q8N2Y6	B2RMV2 Q69YQ0
PDB IDs		2DA1 2DA2 2DA3	Not available
GO Terms Enriched among Interactors		Cytoskeleton Organization Cytoskeleton Microtubule Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Mitotic Spindle Organization Microtubule Organizing Center Microtubule Cytoskeleton Organization Involved In Mitosis Structural Constituent Of Skin Epidermis Cilium Disassembly Centrosome Spindle Organization Cell Division Intermediate Filament Meiotic Spindle Assembly Intermediate Filament Organization Organelle Disassembly Microtubule Organizing Center Organization SUMO Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Meiotic Spindle Organization Spindle Assembly Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process	None