UBE2E2 and RING1

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		UBE2E2	RING1
Description		ubiquitin conjugating enzyme E2 E2	ring finger protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Chromatin Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Protein Monoubiquitination DNA Damage Response Negative Regulation Of Gene Expression Protein Ubiquitination ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Camera-type Eye Morphogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma ( 32296059) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Physiological dysregulation (Mahalanobis distance) ( 32235003) Psychosis (atypical) ( 24132900) Red blood cell count ( 32888494) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 32499647 30718926 30054458 30297969 22885922 28869590 26818947 24509480 23945395) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)	Asthma ( 32296059) Wegener's granulomatosis ( 23740775)
Interacting Genes		77 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUEDC1 CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B HERC5 IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L OTUB1 PCGF2 PDLIM2 PGPEP1 PRAM1 PRKN RBX1 RC3H2 RING1 RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF14 RNF166 RNF168 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBA6 UBOX5 WWP2 XIAP ZNRF1 ZNRF2	33 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 GRSF1 H2AC4 H3-4 NFKBID OGT PCGF3 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K ZIM3
Entrez ID		7325	6015
HPRD ID		06779	03624
Ensembl ID		ENSG00000182247	ENSG00000204227
Uniprot IDs		Q96LR5	A0A1U9X8F2 Q06587
PDB IDs		1Y6L 6W9A
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Cytoplasm Response To Stress Protein K6-linked Ubiquitination Immune System Process Positive Regulation Of Catabolic Process Innate Immune Response Cellular Response To Stress Ubiquitin Binding Positive Regulation Of Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Post-translational Protein Modification Protein Destabilization DNA Damage Response Response To Other Organism Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Viral Process Negative Regulation Of Type I Interferon Production Defense Response	PcG Protein Complex PRC1 Complex Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Nucleus Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Ubiquitination Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Post-translational Protein Modification Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Modification Process Nucleoplasm Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Primary Metabolic Process Heterochromatin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Carbohydrate Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle G1/S Phase Transition RING-like Zinc Finger Domain Binding Regulation Of Phosphorus Metabolic Process Transferase Activity Protein K63-linked Ubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Purine Nucleotide Metabolic Process Histone H2AK119 Ubiquitin Ligase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition
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