UBE2E2 and PGPEP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBE2E2	PGPEP1
Description		ubiquitin conjugating enzyme E2 E2	pyroglutamyl-peptidase I
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Pyroglutamyl-peptidase Activity
	Biological Process	Protein Monoubiquitination DNA Damage Response Negative Regulation Of Gene Expression Protein Ubiquitination ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Proteolysis Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma ( 32296059) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Physiological dysregulation (Mahalanobis distance) ( 32235003) Psychosis (atypical) ( 24132900) Red blood cell count ( 32888494) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 32499647 30718926 30054458 30297969 22885922 28869590 26818947 24509480 23945395) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)	Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413 26961502 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronotype ( 30696823) Coronary artery disease ( 29212778) Gastroesophageal reflux disease ( 34187846 31527586) Growth differentiation factor-15 levels ( 22997280 29628937) Growth differentiation factor-15 levels (conditioned on rs888663) ( 29628937) Hand grip strength ( 29691431) Medication use (beta blocking agents) ( 31015401) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Periodontitis (Mean PAL) ( 24024966) Systemic lupus erythematosus ( 26606652)
Interacting Genes		77 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUEDC1 CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B HERC5 IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L OTUB1 PCGF2 PDLIM2 PGPEP1 PRAM1 PRKN RBX1 RC3H2 RING1 RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF14 RNF166 RNF168 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBA6 UBOX5 WWP2 XIAP ZNRF1 ZNRF2	4 interacting genes: AQP1 NTAQ1 UBE2E2 UBE2E3
Entrez ID		7325	54858
HPRD ID		06779	07141
Ensembl ID		ENSG00000182247	ENSG00000130517
Uniprot IDs		Q96LR5	Q9NXJ5 S4R2Y9 U3KQ24
PDB IDs		1Y6L 6W9A
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Cytoplasm Response To Stress Protein K6-linked Ubiquitination Immune System Process Positive Regulation Of Catabolic Process Innate Immune Response Cellular Response To Stress Ubiquitin Binding Positive Regulation Of Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Post-translational Protein Modification Protein Destabilization DNA Damage Response Response To Other Organism Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Viral Process Negative Regulation Of Type I Interferon Production Defense Response	Protein K11-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Protein Monoubiquitination Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Protein-N-terminal Glutamine Amidohydrolase Activity Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Saliva Secretion Cellular Response To Mercury Ion Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Renal Water Absorption Carbon Dioxide Transmembrane Transporter Activity Glomerulus Vasculature Development Water Transmembrane Transporter Activity Transepithelial Water Transport Hydrogen Peroxide Transmembrane Transport Intracellularly CGMP-activated Cation Channel Activity Carbon Dioxide Transmembrane Transport Lipid Digestion Pancreatic Juice Secretion ISG15-protein Conjugation ISG15 Transferase Activity Ubiquitin-protein Transferase Activity Ankyrin-1 Complex Glycerol Transmembrane Transport Intracellular Water Homeostasis Protein Polyubiquitination Renal Water Transport Regulation Of Saliva Secretion Ammonium Channel Activity Polyol Transmembrane Transport Response To Mercury Ion Ammonium Transmembrane Transport Cellular Response To Salt Stress Positive Regulation Of Digestive System Process Epithelial Fluid Transport Metanephric Nephron Tubule Development Lateral Ventricle Development Water Channel Activity
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