UBE2E2 and TRIM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBE2E2	TRIM3
Description		ubiquitin conjugating enzyme E2 E2	tripartite motif containing 3
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GO Annotations	Cellular Component	Nucleus	Cytoplasm Endosome Early Endosome Golgi Apparatus Dendrite Cell Projection
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Monoubiquitination DNA Damage Response Negative Regulation Of Gene Expression Protein Ubiquitination ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Polyubiquitination Toll-like Receptor Signaling Pathway Nervous System Development Protein Transport Protein Ubiquitination Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma ( 32296059) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Physiological dysregulation (Mahalanobis distance) ( 32235003) Psychosis (atypical) ( 24132900) Red blood cell count ( 32888494) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 32499647 30718926 30054458 30297969 22885922 28869590 26818947 24509480 23945395) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)	Malaria ( 31844061)
Interacting Genes		77 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUEDC1 CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B HERC5 IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L OTUB1 PCGF2 PDLIM2 PGPEP1 PRAM1 PRKN RBX1 RC3H2 RING1 RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF14 RNF166 RNF168 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBA6 UBOX5 WWP2 XIAP ZNRF1 ZNRF2	34 interacting genes: ACTN4 ASL CDKN1A CEP70 CSNK1D CSNK1E DNMT1 FXR1 FXR2 KCTD7 KIF21B LNX1 LRRC8E MYO5A MYO5B ROPN1 TEAD1 TEAD2 TNFAIP3 TPTEP2-CSNK1E TRIM21 TSC1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2G2 UBE2K UBE2U UBE2W UBE2Z USP32
Entrez ID		7325	10612
HPRD ID		06779	05690
Ensembl ID		ENSG00000182247	ENSG00000110171
Uniprot IDs		Q96LR5	B7Z5Y8 O75382
PDB IDs		1Y6L 6W9A	7O0B 7QRW 8AMR
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Cytoplasm Response To Stress Protein K6-linked Ubiquitination Immune System Process Positive Regulation Of Catabolic Process Innate Immune Response Cellular Response To Stress Ubiquitin Binding Positive Regulation Of Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Post-translational Protein Modification Protein Destabilization DNA Damage Response Response To Other Organism Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Viral Process Negative Regulation Of Type I Interferon Production Defense Response	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process ATP Binding Proteolysis Involved In Protein Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Nucleotide Binding Protein Monoubiquitination Macromolecule Catabolic Process Protein K11-linked Ubiquitination Protein Metabolic Process TEAD-YAP Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein K6-linked Ubiquitination ISG15 Transferase Activity Regulation Of TORC1 Signaling Vesicle Transport Along Actin Filament ISG15-protein Conjugation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Catabolic Process Regulation Of TOR Signaling Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process Protein Autoubiquitination Positive Regulation Of Non-canonical Wnt Signaling Pathway Protein K63-linked Ubiquitination Filopodium Tip Protein K27-linked Ubiquitination Translation Regulator Activity Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity TOR Signaling Positive Regulation Of Catabolic Process Negative Regulation Of TOR Signaling Cytoplasmic Stress Granule Nucleus Regulation Of Non-canonical Wnt Signaling Pathway Cellular Response To Interferon-beta
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