RNF6 and KIAA0753

Number of citations: 43 (PubMedID 26871637)
Data Source: BioGRID (two hybrid)

		RNF6	KIAA0753
Name		ring finger protein 6	KIAA0753
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm PML Body Axon Nuclear Membrane Cell Projection	Cytoplasm Endoplasmic Reticulum Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Cilium Centriolar Satellite Ciliary Basal Body
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Nuclear Androgen Receptor Binding Ubiquitin Protein Ligase Activity	Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Axon Extension Protein K27-linked Ubiquitination Positive Regulation Of DNA-templated Transcription Axon Extension Regulation Of Androgen Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination	Centriole Replication Cilium Assembly Cytosolic Ciliogenesis Protein Localization To Centrosome
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	None
GWAS		Sporadic pituitary adenoma ( 26029870 ) Type 2 diabetes ( 24509480 28869590 30297969 30718926 32499647 ) Urate levels (BMI interaction) ( 25811787 )	Familial lung cancer ( 29924316 ) LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883 ) Pulse pressure ( 27841878 28135244 30578418 ) Systolic blood pressure ( 27841878 30578418 )
Interacting Genes		39 interacting genes: AHCYL1 AR CBY2 CCDC33 CCDC57 CDKN1B CEP70 GOLGA2 HOOK2 IKZF1 IKZF3 KIAA0753 KRT15 KRT40 LDOC1 MAGED1 MDFI MEOX2 MID2 MIPOL1 MTUS2 PNMA2 REL RINT1 RPGRIP1 SSX2IP STK4 STX11 TADA2A TFIP11 TNS2 TP53 TRIM23 TRIM27 TRIM37 TSGA10 UBE2C UBE2D1 UBE2H	20 interacting genes: AARD AIRIM BHLHA9 BRPF1 CCHCR1 CT55 FAM161A GCC1 HGS KIFC3 MNS1 RNF6 ROPN1 SMARCD1 SUOX TCHP TEAD4 USHBP1 ZNF114 ZNF777
Entrez ID		6049	9851
HPRD ID		05027	11106
Ensembl ID		ENSG00000127870	ENSG00000198920
Uniprot IDs		A0A024RDP2 A0A0S2Z4G9 Q9Y252	Q2KHM9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Identical Protein Binding Intracellular Transport Cytoskeleton Ubiquitin-protein Transferase Activity Microtubule Organizing Center Organization Cytoplasm Protein Binding Cellular Localization Establishment Of Localization In Cell Centrosome Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Activity Cell Projection Assembly Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cilium Assembly Negative Regulation Of Epithelial Cell Proliferation Intracellular Protein Localization Protein Ubiquitination Transcription Coactivator Activity Cilium Organization Protein Transport Negative Regulation Of Viral Transcription Regulation Of Exit From Mitosis Suppression Of Viral Release By Host Protein Modification By Small Protein Conjugation Organelle Organization Regulation Of Viral Transcription Organelle Assembly Negative Regulation Of Cell Population Proliferation Intracellular Protein Transport Protein Tetramerization Cell Differentiation Involved In Embryonic Placenta Development Plasma Membrane Bounded Cell Projection Assembly	Polymeric Cytoskeletal Fiber