RNF6 and TNS2

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		RNF6	TNS2
Description		ring finger protein 6	tensin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm PML Body Axon Nuclear Membrane Cell Projection	Cytoplasm Plasma Membrane Focal Adhesion Membrane Anchoring Junction
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Nuclear Androgen Receptor Binding Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Zinc Ion Binding Lipid Binding Hydrolase Activity Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Axon Extension Protein K27-linked Ubiquitination Positive Regulation Of DNA-templated Transcription Axon Extension Regulation Of Androgen Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination	Kidney Development Negative Regulation Of Cell Population Proliferation Response To Muscle Activity Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Multicellular Organismal-level Homeostasis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Sporadic pituitary adenoma ( 26029870) Type 2 diabetes ( 24509480 28869590 30297969 30718926 32499647) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		39 interacting genes: AHCYL1 AR CBY2 CCDC33 CCDC57 CDKN1B CEP70 GOLGA2 HOOK2 IKZF1 IKZF3 KIAA0753 KRT15 KRT40 LDOC1 MAGED1 MDFI MEOX2 MID2 MIPOL1 MTUS2 PNMA2 REL RINT1 RPGRIP1 SSX2IP STK4 STX11 TADA2A TFIP11 TNS2 TP53 TRIM23 TRIM27 TRIM37 TSGA10 UBE2C UBE2D1 UBE2H	150 interacting genes: ADCK5 AMMECR1 AP1S2 AQP1 ARID5A ASB3 AXL BAHD1 BLZF1 BRCA1 C11orf87 C1orf94 CATSPER1 CCDC33 CNNM3 COX6B2 CPSF7 CRX CSNK1E CTSZ DCAF11 DCAF8 DDIT4L DLC1 DOK3 DZIP1 DZIP3 EGFR ENKD1 EPB41L4A EPDR1 EPS8L2 ERBB2 ERBB3 ERBB4 FABP7 FAM114A1 FAM228A FASLG FGF21 FGFR1 FOXO1 GATA1 GBA3 GFI1B HOXA1 HOXB9 HOXC8 HUWE1 ID2 IHO1 INO80B ITGB3 ITGB5 ITGB7 KCTD9 KIF1A KIT KPRP KRT76 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP13-2 KRTAP23-1 KRTAP3-1 KRTAP4-4 KRTAP6-3 LASP1 LPXN LUZP4 MET MGAT5B MPEG1 MT2A MTDH MYBPHL MYH7B MYPOP NBPF19 NMU NOTCH2NLA NT5C NUBP2 OBSL1 OTX1 PATZ1 PER1 PHF1 PIN1 PKP1 PLB1 PLK3 PLSCR3 POLR1H POLR3F PRR22 RAMAC RBAK RBPMS REEP6 REL RFT1 RNF6 SDCCAG8 SERTAD2 SH2B3 SHFL SOCS7 SORBS3 SPATA12 SPRY2 SPRY4 SUSD2 SUV39H1 TBC1D16 TCP10L TEKT3 TEKT5 TENT5A TENT5B TFAP2D TLE5 TM4SF19 TRIM8 TSC1 TWSG1 USP54 WAC WDFY3 ZCCHC14 ZIM2 ZNF134 ZNF205 ZNF250 ZNF417 ZNF497 ZNF575 ZNF586 ZNF587 ZNF648 ZNF655 ZNF688 ZNF837
Entrez ID		6049	23371
HPRD ID		05027	16256
Ensembl ID		ENSG00000127870	ENSG00000111077
Uniprot IDs		A0A024RDP2 A0A0S2Z4G9 Q9Y252	Q63HR2
PDB IDs			2DKQ 2KNO 2L6K 2LOZ 3HQC
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Intracellular Transport Cytoskeleton Ubiquitin-protein Transferase Activity Microtubule Organizing Center Organization Cytoplasm Protein Binding Cellular Localization Establishment Of Localization In Cell Centrosome Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Activity Cell Projection Assembly Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cilium Assembly Negative Regulation Of Epithelial Cell Proliferation Intracellular Protein Localization Protein Ubiquitination Transcription Coactivator Activity Cilium Organization Protein Transport Negative Regulation Of Viral Transcription Regulation Of Exit From Mitosis Suppression Of Viral Release By Host Protein Modification By Small Protein Conjugation Organelle Organization Regulation Of Viral Transcription Organelle Assembly Negative Regulation Of Cell Population Proliferation Intracellular Protein Transport Protein Tetramerization Cell Differentiation Involved In Embryonic Placenta Development Plasma Membrane Bounded Cell Projection Assembly	Intermediate Filament Keratin Filament Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Receptor Complex Regulation Of RNA Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Nucleus Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Basal Plasma Membrane Ruffle Membrane Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process ERBB2 Signaling Pathway Cell-substrate Adhesion Salivary Gland Morphogenesis ERBB3:ERBB2 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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