FBXO32 and MYOD1

Number of citations of the paper that reports this interaction (PubMedID 15531760)
0

Data Source:
BioGRID (enzymatic study)

		FBXO32	MYOD1
Description		F-box protein 32	myogenic differentiation 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Z Disc	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Myofibril
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Enzyme Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Cellular Response To Dexamethasone Stimulus	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Muscle Organ Development Myoblast Fate Determination Skeletal Muscle Tissue Development Myoblast Fusion Cellular Response To Starvation Tissue Development Regulation Of Gene Expression Myotube Differentiation Myotube Cell Development Myotube Differentiation Involved In Skeletal Muscle Regeneration Cell Differentiation Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment Skeletal Muscle Tissue Regeneration Positive Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of RNA Splicing Skeletal Muscle Fiber Adaptation Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Positive Regulation Of Myoblast Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II Negative Regulation Of Myoblast Proliferation
Pathways		Neddylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Myogenesis Myogenesis TGFBR3 expression
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935 33627673) Intraocular pressure ( 29617998 29785010 30054594 31959993) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603)	Body mass index ( 26426971) Hodgkin's lymphoma ( 34216518) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		13 interacting genes: CDC34 CDK2 EIF3F KDM2A MLH1 MYC MYOD1 MYOG SH3GL1 SH3GL2 SH3GL3 SKP1 TTN	67 interacting genes: AKAP19 AP1M1 ASCL3 BHLHA15 BHLHE40 BHLHE41 CALM1 CALM2 CALM3 CARM1 CDC34 CDK2 CDK4 CDKN1C CIB2 CREBBP CSRP3 ELSPBP1 EP300 EXOC3L1 FBXO32 FIGLA HAND1 HDAC1 HEY1 HSP90AA1 ID1 ID2 ID3 ID4 IFRD1 IGFN1 JUN KAT2B KAT5 KPNA3 LMO4 MDFI MEF2A MEF2C MOS MYOCD NCOR1 NCOR2 NR2F2 PHB2 POLR2G PRKCA PRMT5 PSMD4 PSME2 RB1 RORA RUNX1 RXRA SETD3 SMAD3 SMAD4 SMAD7 SP1 SRF STAT3 SUV39H1 TCF21 TCF3 TCF4 TWIST1
Entrez ID		114907	4654
HPRD ID		05966	01166
Ensembl ID		ENSG00000156804	ENSG00000129152
Uniprot IDs		I6L984 Q0VAQ6 Q498Y9 Q969P5	P15172
PDB IDs
Enriched GO Terms of Interacting Partners?		Myotube Differentiation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle E-box Binding Striated Muscle Cell Differentiation Skeletal Muscle Cell Differentiation Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Fiber Development Striated Muscle Cell Development Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Fate Commitment Muscle Cell Development Muscle Cell Differentiation Chromosome Organization Positive Regulation Of Striated Muscle Tissue Development Regulation Of Myoblast Fusion Positive Regulation Of Skeletal Muscle Tissue Development DNA-binding Transcription Activator Activity Regulation Of Skeletal Muscle Tissue Development Mitotic Cell Cycle Phase Transition Central Nervous System Development Skeletal Muscle Fiber Development Cell Cycle Phase Transition Cellular Response To Cytokine Stimulus Myotube Cell Development Protein Dimerization Activity Condensed Chromosome Cellular Response To Estradiol Stimulus Regulation Of Striated Muscle Tissue Development Detection Of Mechanical Stimulus Regulation Of Myotube Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Response To Peptide Response To Cytokine Transcription Regulator Complex Male Germ Cell Nucleus Condensed Nuclear Chromosome Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Presynapse Double-strand Break Repair Via Nonhomologous End Joining Euchromatin Identical Protein Binding Positive Regulation Of DNA Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleus Negative Regulation Of Macromolecule Metabolic Process BHLH Transcription Factor Binding Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Rhythmic Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Macromolecule Metabolic Process Nucleoplasm Histone Deacetylase Binding Regulation Of Developmental Process E-box Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Differentiation Cell Differentiation Regulation Of Metabolic Process Circadian Rhythm Positive Regulation Of Cell Differentiation Cellular Developmental Process Transcription Cis-regulatory Region Binding Negative Regulation Of Developmental Process
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