ASAH1 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		ASAH1	HSPB2
Description		N-acylsphingosine amidohydrolase 1	heat shock protein family B (small) member 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Early Endosome Endoplasmic Reticulum Membrane Lysosomal Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Nuclear Receptor Binding N-acylsphingosine Amidohydrolase Activity Fatty Acid Amide Hydrolase Activity	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Keratinocyte Differentiation Negative Regulation Of DNA-templated Transcription Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Ceramide Catabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Cellular Response To Tumor Necrosis Factor	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process
Pathways		Neutrophil degranulation Glycosphingolipid catabolism Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs
Diseases		Farber lipogranulomatosis; Farber disease
GWAS		Atrial fibrillation ( 28416818 29892015 30061737) Night sleep phenotypes ( 27126917) Obesity ( 21552555) Type 2 diabetes ( 32499647)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CAMK1D HSPB2 SETDB1 SMPD1 SRPK1 TSC22D1	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		427	3316
HPRD ID		01969	03712
Ensembl ID		ENSG00000104763	ENSG00000170276
Uniprot IDs		A0A1B0GUE3 A8K0B6 Q13510 Q53H01	A8KAH6 Q16082
PDB IDs		5U7Z 6MHM	6F2R
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Phosphatidylcholine Phospholipase C Activity Regulation Of Viral Life Cycle Positive Regulation Of Apoptotic Process Acid Sphingomyelin Phosphodiesterase Activity Positive Regulation Of Viral Process Regulation Of Viral Process Termination Of Signal Transduction Somatic Muscle Development Positive Regulation Of Endocytosis Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Sphingomyelin Catabolic Process Lamellar Body Sphingomyelin Phosphodiesterase Activity Histone H3K9 Monomethyltransferase Activity Endolysosome Histone H3K9me2 Methyltransferase Activity Positive Regulation Of Respiratory Burst Positive Regulation Of CREB Transcription Factor Activity Histone H3K9 Methyltransferase Activity	Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding
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