ASAH1

Gene Name		N-acylsphingosine amidohydrolase (acid ceramidase) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Catalytic Activity Ceramidase Activity
	Biological Process	Sphingolipid Metabolic Process Ceramide Metabolic Process Glycosphingolipid Metabolic Process Response To Organic Substance Lung Development Small Molecule Metabolic Process
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism
Drugs
Diseases
GWAS		Obesity ( 21552555)
Protein-protein Interactions		5 interactors: CAMK1D SETDB1 SMPD1 SRPK1 TSC22D1
Entrez ID		427
HPRD ID		01969
Ensembl ID		ENSG00000104763
Uniprot IDs		A8K0B6 E7EMM4 Q13510 Q53H01
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Sphingomyelin Catabolic Process Positive Regulation Of Respiratory Burst Sperm Chromatin Condensation Histone H3-K9 Trimethylation Regulation Of Apoptotic Process Regulation Of Respiratory Burst Regulation Of Cell Death Sphingomyelin Metabolic Process Regulation Of Metabolic Process Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Protein Dephosphorylation Histone H3-K9 Methylation Inner Cell Mass Cell Proliferation Positive Regulation Of Viral Genome Replication Positive Regulation Of Neutrophil Chemotaxis Regulation Of RNA Metabolic Process Peptidyl-lysine Trimethylation Positive Regulation Of Granulocyte Chemotaxis Phospholipid Catabolic Process Blastocyst Growth Sphingolipid Catabolic Process Spermatid Nucleus Differentiation Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Membrane Lipid Catabolic Process
Tagcloud ?		adjuvant apoptotic best breast cancers ceramidase ceramide converting dcis even generally good improved invasive luminal mainly metabolism moreover overexpressed phenotype pre pro prognosis recurrences sphingolipid sphingosine subtype subtypes valuable