ASAH1 and SETDB1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ASAH1	SETDB1
Gene Name		N-acylsphingosine amidohydrolase (acid ceramidase) 1	SET domain, bifurcated 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Lumen Extracellular Vesicular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Catalytic Activity Ceramidase Activity	DNA Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity
	Biological Process	Sphingolipid Metabolic Process Ceramide Metabolic Process Glycosphingolipid Metabolic Process Response To Organic Substance Lung Development Small Molecule Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Inner Cell Mass Cell Proliferation Chromatin Organization Transcription, DNA-templated Histone H3-K9 Trimethylation Bone Development
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Obesity ( 21552555)	Chronic kidney disease ( 20383146) Melanoma ( 21983785)
Protein-Protein Interactions		5 interactors: CAMK1D SETDB1 SMPD1 SRPK1 TSC22D1	107 interactors: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 C11orf1 CBX8 CCDC106 CDK4 CDKN1A CLSTN1 CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 HDAC1 HDAC2 HIST1H3A HIST2H3A HIST3H3 HIST4H4 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPARG PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VIM ZFP64 ZNF24
Entrez ID		427	9869
HPRD ID		01969	06828
Ensembl ID		ENSG00000104763	ENSG00000143379
Uniprot IDs		A8K0B6 E7EMM4 Q13510 Q53H01	Q15047
PDB IDs			3DLM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Sphingomyelin Catabolic Process Positive Regulation Of Respiratory Burst Sperm Chromatin Condensation Histone H3-K9 Trimethylation Regulation Of Apoptotic Process Regulation Of Respiratory Burst Regulation Of Cell Death Sphingomyelin Metabolic Process Regulation Of Metabolic Process Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Protein Dephosphorylation Histone H3-K9 Methylation Inner Cell Mass Cell Proliferation Positive Regulation Of Viral Genome Replication Positive Regulation Of Neutrophil Chemotaxis Regulation Of RNA Metabolic Process Peptidyl-lysine Trimethylation Positive Regulation Of Granulocyte Chemotaxis Phospholipid Catabolic Process Blastocyst Growth Sphingolipid Catabolic Process Spermatid Nucleus Differentiation Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Membrane Lipid Catabolic Process	Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Methylation Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Chromosome Organization Regulation Of RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of Proteolysis DNA Modification Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Response To Stress Transcription, DNA-templated Gene Silencing Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Chromatin Silencing Metabolic Process RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Cell Cycle
Tagcloud ?		adjuvant apoptotic best breast cancers ceramidase ceramide converting dcis even generally good improved invasive luminal mainly metabolism moreover overexpressed phenotype pre pro prognosis recurrences sphingolipid sphingosine subtype subtypes valuable	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified
Tagcloud (Difference) ?		adjuvant apoptotic best breast cancers ceramidase ceramide converting dcis even generally good improved invasive luminal mainly metabolism moreover overexpressed phenotype pre pro prognosis recurrences sphingolipid sphingosine subtype subtypes valuable	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified
Tagcloud (Intersection) ?