MEIS1 and TLX3

Number of citations of the paper that reports this interaction (PMID 15466398)
22

Data Source:
HPRD (in vitro)

		MEIS1	TLX3
Gene Name		Meis homeobox 1	T-cell leukemia homeobox 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding Sequence-specific DNA Binding
	Biological Process	Angiogenesis Lens Morphogenesis In Camera-type Eye Transcription From RNA Polymerase II Promoter Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Definitive Hemopoiesis	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Transcription, DNA-templated Central Nervous System Development Respiratory Gaseous Exchange Negative Regulation Of Neuron Differentiation Neuron Fate Specification
Pathways
Drugs
Diseases
GWAS		PR interval ( 20062060 23139255) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		27 interactors: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	16 interactors: DENND4A GTF2A1L HIST1H2BJ HNRNPUL1 HOPX ING4 IRF9 LMO2 MEIS1 PPP1CC PQBP1 SNTA1 SP1 TLE1 TLE2 ZNF41
Entrez ID		4211	30012
HPRD ID		03442	06868
Ensembl ID		ENSG00000143995	ENSG00000164438
Uniprot IDs		F5GYS8 F8W8U3 O00470	O43711
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Pattern Specification Process Embryonic Morphogenesis Transcription, DNA-templated Skeletal System Development Embryonic Skeletal System Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Multicellular Organismal Development System Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryonic Skeletal System Morphogenesis RNA Metabolic Process Limb Development Embryo Development Gene Expression Organ Development Developmental Process Organ Morphogenesis Embryonic Limb Morphogenesis Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Macromolecule Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Proximal/distal Pattern Formation Positive Regulation Of Transcription, DNA-templated Skeletal System Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Metabolic Process Embryonic Organ Development Cellular Nitrogen Compound Metabolic Process Chordate Embryonic Development Nitrogen Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Embryonic Forelimb Morphogenesis	Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Megakaryocyte Differentiation Definitive Hemopoiesis Trophectodermal Cell Differentiation Regulation Of Cellular Process Cellular Metabolic Process Blastocyst Formation Sequestering Of Nodal From Receptor Via Nodal Binding Regulation Of Vasoconstriction By Circulating Norepinephrine Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nodal Signaling Pathway Negative Regulation Of Myeloid Cell Differentiation Blastocyst Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Peptidyl-cysteine S-nitrosylation Camera-type Eye Morphogenesis Organ Morphogenesis Notch Signaling Pathway Determination Of Left/right Asymmetry In Lateral Mesoderm Positive Regulation Of Skeletal Muscle Tissue Regeneration Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nodal Signaling Pathway Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Regulation Of Heart Contraction
Tagcloud ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	abt alls asparaginase attractive bcl bh3 challenge chemotherapeutic correspondence decreases dexamethasone doxorubicin driven exploited gradually highlights hoxa immature intensified loucy lymphoblastic mimetic mostly precursors refractory shows subtypes synergistic tal1
Tagcloud (Difference) ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	abt alls asparaginase attractive bcl bh3 challenge chemotherapeutic correspondence decreases dexamethasone doxorubicin driven exploited gradually highlights hoxa immature intensified loucy lymphoblastic mimetic mostly precursors refractory shows subtypes synergistic tal1
Tagcloud (Intersection) ?