MEIS1 and HOXA13

Number of citations of the paper that reports this interaction (PMID 15617687)
15

Data Source:
HPRD (in vivo, two hybrid)

		MEIS1	HOXA13
Gene Name		Meis homeobox 1	homeobox A13
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Nucleoplasm Intermediate Filament Cytoskeleton
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Angiogenesis Lens Morphogenesis In Camera-type Eye Transcription From RNA Polymerase II Promoter Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Definitive Hemopoiesis	Skeletal System Development Vasculogenesis Endothelial Cell Morphogenesis Tissue Homeostasis Ventricular Septum Development Transcription, DNA-templated Regulation Of BMP Signaling Pathway Male Genitalia Development Embryonic Forelimb Morphogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Inner Ear Development Artery Morphogenesis Branching Involved In Prostate Gland Morphogenesis Endothelial Cell Fate Specification Positive Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
Drugs
Diseases
GWAS		PR interval ( 20062060 23139255) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		27 interactors: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	6 interactors: MEIS1 MEIS2 MEIS3 SMAD1 SMAD2 SMAD5
Entrez ID		4211	3209
HPRD ID		03442	00847
Ensembl ID		ENSG00000143995
Uniprot IDs		F5GYS8 F8W8U3 O00470	P31271 Q6DI00
PDB IDs			2L7Z
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Pattern Specification Process Embryonic Morphogenesis Transcription, DNA-templated Skeletal System Development Embryonic Skeletal System Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Multicellular Organismal Development System Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryonic Skeletal System Morphogenesis RNA Metabolic Process Limb Development Embryo Development Gene Expression Organ Development Developmental Process Organ Morphogenesis Embryonic Limb Morphogenesis Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Macromolecule Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Proximal/distal Pattern Formation Positive Regulation Of Transcription, DNA-templated Skeletal System Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Metabolic Process Embryonic Organ Development Cellular Nitrogen Compound Metabolic Process Chordate Embryonic Development Nitrogen Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Embryonic Forelimb Morphogenesis	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Osteoblast Fate Commitment Primary MiRNA Processing Embryonic Pattern Specification Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development SMAD Protein Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Skeletal System Development Kidney Epithelium Development Response To Growth Factor RNA Metabolic Process Regulation Of Cell Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To BMP Stimulus Positive Regulation Of Metabolic Process Gene Expression Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Bone Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Gene Silencing By MiRNA Cell Fate Commitment Cellular Response To DsRNA Regulation Of Transcription, DNA-templated Kidney Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Posttranscriptional Gene Silencing Regulation Of RNA Metabolic Process Renal System Development Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Urogenital System Development
Tagcloud ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	a2 anxa2 cancerous carcinogenesis coexpression cohorts cox curve dismutase employed escc esophageal hazards homeobox ihc kaplanmeier positively predictors predicts proportional qpcr shorter sixth sod2 squamous superoxide tnm validation
Tagcloud (Difference) ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	a2 anxa2 cancerous carcinogenesis coexpression cohorts cox curve dismutase employed escc esophageal hazards ihc kaplanmeier positively predictors predicts proportional qpcr shorter sixth sod2 squamous superoxide tnm validation
Tagcloud (Intersection) ?		homeobox