TLX3 and ATP6V0D1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLX3	ATP6V0D1
Description		T cell leukemia homeobox 3	ATPase H+ transporting V0 subunit d1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosome Lysosomal Membrane Early Endosome Centrosome Synaptic Vesicle Endosome Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Plasma Membrane Proton-transporting V-type ATPase Complex Axon Terminus Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Protein-containing Complex Binding Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Neuron Differentiation Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification GABAergic Neuron Differentiation	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Transport Vacuolar Acidification Regulation Of Macroautophagy Cell Projection Organization Cellular Response To Increased Oxygen Levels Homeostatic Process Cilium Assembly Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes XBP1(S) activates chaperone genes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs			Tiludronic acid
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Body size at age 10 ( 32376654)	Disease progression in age-related macular degeneration ( 29346644) Empathy quotient ( 29527006) Medication use (thyroid preparations) ( 31015401) Refractive error ( 32231278)
Interacting Genes		108 interacting genes: ACTMAP ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C2orf42 CEACAM6 CFAP68 CIMIP2B CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNF1B HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KCNJ5-AS1 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NFIC NFIX NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPMIP9 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 THTPA TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44	10 interacting genes: ADRB2 ATXN1 DMRT3 GATA1 IHO1 IKZF3 LIG4 RBPMS TLE5 TLX3
Entrez ID		30012	9114
HPRD ID		06868	06121
Ensembl ID		ENSG00000164438	ENSG00000159720
Uniprot IDs		O43711	P61421
PDB IDs			6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Chromatin	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Cell Differentiation Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Developmental Process Regulation Of Developmental Process Neuron Fate Specification Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Primary Metabolic Process Regulation Of Bone Mineralization Nucleus Regulation Of Multicellular Organismal Development Nucleobase-containing Compound Biosynthetic Process Regulation Of Gene Expression Transcription By RNA Polymerase II Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Leukocyte Differentiation Basophil Differentiation Eosinophil Fate Commitment Regulation Of Cell Development Mononuclear Cell Differentiation DNA Binding Regulation Of Primitive Erythrocyte Differentiation Regulation Of Cell Differentiation Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Adult Locomotory Behavior Cell Fate Specification Regulation Of Ossification DNA-templated Transcription Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Identical Protein Binding System Development Sequence-specific DNA Binding Primitive Erythrocyte Differentiation Regulation Of Definitive Erythrocyte Differentiation DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination
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