TLX3 and PSMB11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLX3	PSMB11
Description		T cell leukemia homeobox 3	proteasome subunit beta 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Neuron Differentiation Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification GABAergic Neuron Differentiation	Proteolysis T Cell Differentiation In Thymus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process CD8-positive, Alpha-beta T Cell Differentiation Proteolysis Involved In Protein Catabolic Process
Pathways			Proteasome assembly Proteasome assembly
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Body size at age 10 ( 32376654)	Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		108 interacting genes: ACTMAP ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C2orf42 CEACAM6 CFAP68 CIMIP2B CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNF1B HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KCNJ5-AS1 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NFIC NFIX NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPMIP9 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 THTPA TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44	5 interacting genes: ATG5 HGS PITX1 PROP1 TLX3
Entrez ID		30012	122706
HPRD ID		06868	19472
Ensembl ID		ENSG00000164438	ENSG00000222028
Uniprot IDs		O43711	A5LHX3 B3KVC3
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Chromatin	Pituitary Gland Development Branchiomeric Skeletal Muscle Development Myoblast Fate Commitment Sequence-specific Double-stranded DNA Binding Somatotropin Secreting Cell Differentiation Central Nervous System Development Hypophysis Morphogenesis ESCRT-0 Complex Phagocytic Vesicle Lumen Macroautophagy Negative Regulation Of Autophagic Cell Death Otolith Development Phagophore Atg8-family Ligase Activity Response To Fluoride Positive Regulation Of Viral Translation Negative Stranded Viral RNA Replication Cellular Response To Nitrosative Stress Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression System Development Hypothalamus Cell Differentiation Positive Regulation Of Stress Granule Assembly Chaperone-mediated Autophagy Response To Iron(II) Ion Viral RNA Genome Replication Atg12-Atg5-Atg16 Complex Positive Regulation Of Mucus Secretion DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of Mucus Secretion Response To Nitrosative Stress Gland Development Adenohypophysis Development Autophagy Ventricular Cardiac Muscle Cell Development Cellular Response To Nitrogen Starvation Cellular Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Secretion Negative Thymic T Cell Selection Regulation Of Stress Granule Assembly Regulation Of Respiratory Gaseous Exchange By Nervous System Process GABAergic Neuron Differentiation Cardiac Muscle Cell Apoptotic Process Negative T Cell Selection Transferase Complex
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