MEIS1 and TLX2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		MEIS1	TLX2
Gene Name		Meis homeobox 1	T-cell leukemia homeobox 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Cellular_component Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	Molecular_function Sequence-specific DNA Binding
	Biological Process	Angiogenesis Lens Morphogenesis In Camera-type Eye Transcription From RNA Polymerase II Promoter Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Definitive Hemopoiesis	Mesoderm Formation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Biological_process Enteric Nervous System Development Negative Regulation Of Dendrite Morphogenesis
Pathways
Drugs
Diseases
GWAS		PR interval ( 20062060 23139255) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		27 interactors: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	9 interactors: GTF2A1L IRF6 IRF9 MCM4 MEIS1 POU2F1 TLE1 YWHAH ZNF502
Entrez ID		4211	3196
HPRD ID		03442	07254
Ensembl ID		ENSG00000143995	ENSG00000115297
Uniprot IDs		F5GYS8 F8W8U3 O00470	F1T0F2 O43763
PDB IDs			3A03
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Pattern Specification Process Embryonic Morphogenesis Transcription, DNA-templated Skeletal System Development Embryonic Skeletal System Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Multicellular Organismal Development System Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryonic Skeletal System Morphogenesis RNA Metabolic Process Limb Development Embryo Development Gene Expression Organ Development Developmental Process Organ Morphogenesis Embryonic Limb Morphogenesis Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Macromolecule Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Proximal/distal Pattern Formation Positive Regulation Of Transcription, DNA-templated Skeletal System Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Metabolic Process Embryonic Organ Development Cellular Nitrogen Compound Metabolic Process Chordate Embryonic Development Nitrogen Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Embryonic Forelimb Morphogenesis	Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Lens Morphogenesis In Camera-type Eye Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Glucocorticoid Catabolic Process Lens Development In Camera-type Eye Regulation Of Metabolic Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Transcription, DNA-templated Interferon-gamma-mediated Signaling Pathway Camera-type Eye Morphogenesis Cellular Response To Interferon-gamma Positive Regulation Of Macromolecule Biosynthetic Process Eye Morphogenesis Response To Interferon-gamma Positive Regulation Of Cellular Biosynthetic Process Olfactory Placode Formation Negative Regulation Of Neuron Differentiation Organ Development Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Dendrite Morphogenesis Lens Induction In Camera-type Eye Type I Interferon Biosynthetic Process DNA Unwinding Involved In DNA Replication Positive Regulation Of Metabolic Process Negative Regulation Of Neurogenesis Organ Morphogenesis Keratinocyte Proliferation Negative Regulation Of Anoikis Type I Interferon Production Negative Regulation Of Dendrite Development
Tagcloud ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9 sox9a specify statoacoustic ultricular uncovered zebrafish
Tagcloud (Difference) ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9 sox9a specify statoacoustic ultricular uncovered zebrafish
Tagcloud (Intersection) ?