TLX3 and MSX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLX3	MSX2
Description		T cell leukemia homeobox 3	msh homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Transcription Regulator Complex Cytosol Nuclear Speck
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Neuron Differentiation Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification GABAergic Neuron Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation Chondrocyte Development Osteoblast Development Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endochondral Bone Growth Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Signal Transduction Involved In Regulation Of Gene Expression Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Embryonic Nail Plate Morphogenesis Wound Healing Odontogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Embryonic Morphogenesis Stem Cell Differentiation Cartilage Development Positive Regulation Of Timing Of Catagen Bone Trabecula Formation Bone Morphogenesis Cranial Suture Morphogenesis Frontal Suture Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Epithelium Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Enamel Mineralization Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Activation Of Meiosis Mesenchymal Cell Apoptotic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process
Pathways			Regulation of RUNX2 expression and activity
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Enlarged parietal foramina/cranium bifidum Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Body size at age 10 ( 32376654)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alzheimer's disease ( 33074286) Blond vs. brown/black hair color ( 30531825) Chin dimples ( 27182965) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Red vs. brown/black hair color ( 30531825) Resistant hypertension ( 30237584) Stroke ( 26089329)
Interacting Genes		108 interacting genes: ACTMAP ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C2orf42 CEACAM6 CFAP68 CIMIP2B CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNF1B HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KCNJ5-AS1 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NFIC NFIX NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPMIP9 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 THTPA TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44	53 interacting genes: ATXN1 CCDC102B CEBPA CLIC3 DLX2 DLX5 EPHB6 FBXW2 FOXH1 GATA2 GTF2F1 GTF2F2 HOXC9 LENG8 MAGED1 MAPK1 MAPK1IP1L MGAT5B MSX1 NAF1 NR3C1 PATZ1 PIAS2 PITX1 POLR3D POU1F1 POU2AF1 POU2F2 POU6F2 PPARG PRR13 RBPMS2 RHOXF2 RUNX2 SMAP2 SOX5 SPEN TCF7L2 TENT5D TLE1 TLE2 TLE5 TLX3 TOLLIP TSSK3 VEZF1 XRCC5 XRCC6 YTHDF1 ZBTB17 ZC3H10 ZDHHC2 ZFHX3
Entrez ID		30012	4488
HPRD ID		06868	00421
Ensembl ID		ENSG00000164438	ENSG00000120149
Uniprot IDs		O43711	D6RIS4 P35548
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Chromatin	Regulation Of RNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis DNA-templated Transcription Sequence-specific Double-stranded DNA Binding Nucleoplasm Cell Fate Commitment Positive Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation GABAergic Neuron Differentiation Developmental Process Transcription Factor TFIIF Complex Protein-DNA Complex
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