TLX3 and DENND4A

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TLX3	DENND4A
Gene Name		T-cell leukemia homeobox 3	DENN/MADD domain containing 4A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	Protein Binding Sequence-specific DNA Binding	DNA Binding Rab Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Transcription, DNA-templated Central Nervous System Development Respiratory Gaseous Exchange Negative Regulation Of Neuron Differentiation Neuron Fate Specification	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Rab GTPase Activity
Pathways
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		16 interactors: DENND4A GTF2A1L HIST1H2BJ HNRNPUL1 HOPX ING4 IRF9 LMO2 MEIS1 PPP1CC PQBP1 SNTA1 SP1 TLE1 TLE2 ZNF41	5 interactors: CEBPE PCBD1 SERTAD1 TLX3 YWHAG
Entrez ID		30012	10260
HPRD ID		06868	02662
Ensembl ID		ENSG00000164438	ENSG00000174485
Uniprot IDs		O43711	Q05C90 Q7Z401
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Megakaryocyte Differentiation Definitive Hemopoiesis Trophectodermal Cell Differentiation Regulation Of Cellular Process Cellular Metabolic Process Blastocyst Formation Sequestering Of Nodal From Receptor Via Nodal Binding Regulation Of Vasoconstriction By Circulating Norepinephrine Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nodal Signaling Pathway Negative Regulation Of Myeloid Cell Differentiation Blastocyst Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Peptidyl-cysteine S-nitrosylation Camera-type Eye Morphogenesis Organ Morphogenesis Notch Signaling Pathway Determination Of Left/right Asymmetry In Lateral Mesoderm Positive Regulation Of Skeletal Muscle Tissue Regeneration Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nodal Signaling Pathway Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Regulation Of Heart Contraction	Positive Regulation Of Transcription, DNA-templated Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression L-phenylalanine Catabolic Process Positive Regulation Of Cellular Biosynthetic Process L-phenylalanine Metabolic Process Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Metabolic Process Regulation Of Respiratory System Process Regulation Of Protein Homodimerization Activity Macrophage Differentiation Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Neuron Differentiation Cytokine Biosynthetic Process Regulation Of Respiratory Gaseous Exchange Regulation Of RNA Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cytokine Metabolic Process Neuron Fate Specification Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Pteridine-containing Compound Biosynthetic Process Regulation Of Neurogenesis RNA Biosynthetic Process Regulation Of Protein Kinase Activity Aromatic Amino Acid Family Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Respiratory Gaseous Exchange Regulation Of Cell Development Positive Regulation Of Mitochondrion Organization Pteridine-containing Compound Metabolic Process
Tagcloud ?		abt alls asparaginase attractive bcl bh3 challenge chemotherapeutic correspondence decreases dexamethasone doxorubicin driven exploited gradually highlights hoxa immature intensified loucy lymphoblastic mimetic mostly precursors refractory shows subtypes synergistic tal1
Tagcloud (Difference) ?		abt alls asparaginase attractive bcl bh3 challenge chemotherapeutic correspondence decreases dexamethasone doxorubicin driven exploited gradually highlights hoxa immature intensified loucy lymphoblastic mimetic mostly precursors refractory shows subtypes synergistic tal1
Tagcloud (Intersection) ?