MEIS1 and HOXA7

Number of citations of the paper that reports this interaction (PMID 9405651)
46

Data Source:
HPRD (in vivo)

		MEIS1	HOXA7
Gene Name		Meis homeobox 1	homeobox A7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Angiogenesis Lens Morphogenesis In Camera-type Eye Transcription From RNA Polymerase II Promoter Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Definitive Hemopoiesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Leukocyte Migration Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Skeletal System Morphogenesis Stem Cell Differentiation
Pathways
Drugs
Diseases
GWAS		PR interval ( 20062060 23139255) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		27 interactors: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	5 interactors: GMNN JUNB MEIS1 NPM1 PEX5
Entrez ID		4211	3204
HPRD ID		03442	00838
Ensembl ID		ENSG00000143995	ENSG00000122592
Uniprot IDs		F5GYS8 F8W8U3 O00470	P31268
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Pattern Specification Process Embryonic Morphogenesis Transcription, DNA-templated Skeletal System Development Embryonic Skeletal System Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Multicellular Organismal Development System Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryonic Skeletal System Morphogenesis RNA Metabolic Process Limb Development Embryo Development Gene Expression Organ Development Developmental Process Organ Morphogenesis Embryonic Limb Morphogenesis Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Macromolecule Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Proximal/distal Pattern Formation Positive Regulation Of Transcription, DNA-templated Skeletal System Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Metabolic Process Embryonic Organ Development Cellular Nitrogen Compound Metabolic Process Chordate Embryonic Development Nitrogen Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Embryonic Forelimb Morphogenesis	Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Negative Regulation Of Protein Homotetramerization Regulation Of Cell Cycle Protein Import Into Peroxisome Matrix, Translocation Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Developmental Process Protein Complex Assembly Protein Import Into Peroxisome Matrix, Docking Myeloid Cell Differentiation Organ Development Negative Regulation Of Protein Homooligomerization Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Protein Import Into Peroxisome Membrane Protein To Membrane Docking Peroxisomal Membrane Transport Osteoblast Proliferation Negative Regulation Of Protein Oligomerization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Centriole Replication Embryonic Process Involved In Female Pregnancy Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Protein Import Into Peroxisome Matrix Blood Vessel Morphogenesis Protein Oligomerization Negative Regulation Of Centrosome Duplication Megakaryocyte Development Negative Regulation Of Cell Cycle System Development Blood Vessel Development Cellular Component Assembly Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Vasculature Development Megakaryocyte Differentiation Definitive Hemopoiesis Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Regulation Of RNA Metabolic Process Trophectodermal Cell Differentiation CENP-A Containing Nucleosome Assembly Labyrinthine Layer Blood Vessel Development Very Long-chain Fatty Acid Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Negative Regulation Of Cellular Metabolic Process Lens Morphogenesis In Camera-type Eye
Tagcloud ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	cdk2 cdk4 changes contribute conversely cyclin define diagnostic downregulation e1 endogenous forced hcc hepatocellular hepg2 knockdown morphogenesis observations organogenesis progression proliferation promising promoted qgy qsg roles sirna strategies
Tagcloud (Difference) ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations	cdk2 cdk4 changes contribute conversely cyclin define diagnostic downregulation e1 endogenous forced hcc hepatocellular hepg2 knockdown morphogenesis observations organogenesis progression proliferation promising promoted qgy qsg roles sirna strategies
Tagcloud (Intersection) ?		hox