MEIS1 and HOXA11

Number of citations of the paper that reports this interaction (PubMedID 16087734)
77

Data Source:
HPRD (two hybrid)

		MEIS1	HOXA11
Description		Meis homeobox 1	homeobox A11
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Eye Development Lens Morphogenesis In Camera-type Eye Regulation Of DNA-templated Transcription Brain Development Locomotory Behavior Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Hemopoiesis Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Definitive Hemopoiesis Cell Growth Involved In Cardiac Muscle Cell Development	Skeletal System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Chondrocyte Differentiation Chondrocyte Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Single Fertilization Mesodermal Cell Fate Specification Male Gonad Development Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Positive Regulation Of Cell Development Embryonic Limb Morphogenesis Prostate Gland Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Response To Testosterone Embryonic Forelimb Morphogenesis Embryonic Digit Morphogenesis Response To Estrogen Positive Regulation Of DNA-templated Transcription Cell Development Developmental Growth Uterus Development Embryonic Skeletal Joint Morphogenesis Bone Development Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Chondrocyte Development
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Formation of the ureteric bud
Drugs
Diseases			Radioulnar synostosis with amegakaryocytic thrombocytopenia
GWAS		Adolescent idiopathic scoliosis ( 28334814) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Coffee consumption ( 31046077) Colorectal cancer (diet interaction) ( 24743840) Early spontaneous preterm birth ( 31194736) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Endometriosis ( 27506219) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 29891935) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Insomnia ( 32332799 27992416) Insomnia complaints ( 28604731) Insomnia complaints (continuous) ( 28604731) Insomnia complaints (dichotomous) ( 28604731) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29785010) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Photic sneeze reflex ( 27182965) Platelet count ( 32888494) PR interval ( 20062060 30679814 32439900 21347284 30046033 23139255) PR segment duration ( 24850809) Relative amplitude of rest-activity cycles ( 30120083) Resting heart rate ( 27798624) Restless legs syndrome ( 17637780 33239738 29029846 21779176) Sleep activity levels ( 33075057) Sleep duration ( 30531941) Sleep start time ( 33075057) Sleep traits (multi-trait analysis) ( 27992416) Systolic blood pressure ( 30224653 30578418) Triglycerides ( 30275531) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	A body shape index ( 34021172) Heel bone mineral density ( 30598549 28869591) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	5 interacting genes: CREBBP GMNN MEIS1 PGBD3 YY1
Entrez ID		4211	3207
HPRD ID		03442	00846
Ensembl ID		ENSG00000143995	ENSG00000005073
Uniprot IDs		O00470	P31270
PDB IDs		4XRS 5EGO
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Chromatin Regionalization Pattern Specification Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Embryonic Skeletal System Morphogenesis Animal Organ Morphogenesis DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Skeletal System Morphogenesis Embryonic Organ Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Skeletal System Development Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Animal Organ Development Prostate Gland Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Developmental Process Regulation Of Macromolecule Metabolic Process Nucleus Proximal/distal Pattern Formation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Response To Testosterone Sequence-specific DNA Binding Embryonic Limb Morphogenesis System Development Gland Development Limb Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure	Chromatin Binding DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of DNA Metabolic Process Cellular Response To UV Anatomical Structure Morphogenesis Sequence-specific DNA Binding Animal Organ Morphogenesis Recombinational Repair Positive Regulation Of DNA Repair Histone H3K18 Acetyltransferase Activity Response To UV N-terminal Peptidyl-lysine Acetylation Cellular Response To Light Stimulus Double-strand Break Repair Via Homologous Recombination Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Immunoglobulin Heavy Chain V-D-J Recombination Response To Prostaglandin F Regulation Of DNA Replication DNA Replication Preinitiation Complex Assembly Cellular Response To Radiation Hemopoiesis MRF Binding Transcription Corepressor Activity Double-strand Break Repair Regulation Of DNA Repair DNA Recombination Positive Regulation Of Chromatin Binding Chromatin Immunoglobulin V(D)J Recombination Positive Regulation Of DNA Metabolic Process Cell Growth Involved In Cardiac Muscle Cell Development Peptidyl-lysine Acetylation Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Heat Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase I Regulation Of RNA Biosynthetic Process N-terminal Protein Amino Acid Acetylation Response To Light Stimulus Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Definitive Hemopoiesis Lens Morphogenesis In Camera-type Eye Regulation Of DNA Strand Elongation Negative Regulation Of Interferon-beta Production DNA-binding Transcription Repressor Activity Four-way Junction DNA Binding
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